To explore the potential vitiligo treatment mechanism of Piperine in Piperis Longi Fructus via network pharmacology and bioinformatics strategies  

作　　者：Ji-Hong Li Jia-Yu Zhang Yuan-Xia Zou 

机构地区：[1]Department of Dermatology,Leshan Traditional Chinese Medicine Hospital,Leshan,Sichuan,614001,China [2]The First Clinical Medical College of Yunnan University of Traditional Chinese Medicine,Kunming,Yunnan,650051,China [3]Department of Newborn Medicine,Hospital(T.C.M)Affiliated to Southwest Medical University,Luzhou,Sichuan,646000,Chin

出　　处：《TMR Integrative Medicine》2021年第10期1-10,共10页TMR整合医学

摘　　要：Objective:To explore the mechanism of Piperine of Piperis Longi Fructus in the treatment of vitiligo based on network pharmacology and transcriptome.Methods:Piperine,the active component of Piperis Longi Fructus,was screened from Traditional Chinese Medicine Systems Pharmacology,and the target network and protein interaction network of piperine-vitiligo were constructed.PPI analyzed the cross targets,GO function,and KEGG pathway analysis.In the GEO database,vitiligo gene expression profile chips GSE65127 and GSE75819 were selected for differential gene screening and gene set enrichment analysis.The potential key signal pathways of piperine in the treatment of vitiligo were identified by transcriptome microarray data verification.Results:31 potential targets of piperine in the treatment of vitiligo were found,of which 9 targets such as ESR1,AKT1,and IGF1 were closely related to the treatment of vitiligo.Enrichment analysis showed that signal pathways such as PI3K-Akt,MAPK,and Melanogenesis were related to piperine's mechanism in treating vitiligo.The cross-validation of chip analysis results confirmed that Melanogenesis is a potential key signal pathway for piperine in vitiligo treatment.Conclusion:This study discusses the potential targets and signal pathways of piperine in the treatment of vitiligo,which helps clarify the mechanism of piperine in the treatment of vitiligo and provides a theoretical basis for the clinical treatment of vitiligo.It also provides direction for the research and development of new drugs for vitiligo.

关 键 词：PIPERINE VITILIGO Network pharmacology TRANSCRIPTOME Action mechanism 

分 类 号：R75[医药卫生—皮肤病学与性病学]