基于直线加速器立体定向放疗计划设计与评估的若干物理问题  

Physics issues on plan design and evaluation for stereotactic radiotherapy based on linear accelerator

作　　者：王雪桃[1] 王辛[1] 柏森[1] 钟仁明[1] Wang Xuetao;Wang Xin;Bai Sen;Zhong Renming(Department of Radiation Oncology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西临床医学院/华西医院放疗科,成都610041

出　　处：《中华放射肿瘤学杂志》2021年第3期221-229,共9页Chinese Journal of Radiation Oncology

基　　金：四川省卫生健康委员会科研课题(20PJ009)。

摘　　要：立体定向放射治疗(SRT)又称立体定向消融放疗(SABR),包括颅内立体定向放射外科和体部立体定向放疗(SBRT)。该技术具有分次剂量大、治疗次数少、等效生物剂量高、靶区外剂量跌落迅速等特点,可通过γ刀、Cyberknife、Tomotherapy、Vero 4D RT系统等相对特殊的设备实现,而基于直线加速器进行SBRT则更为普遍。SRT在计划设计和评估等相关物理问题与常规放疗不同,因此,有必要对其进行讨论,以指导临床应用和研究。Stereotactic radiotherapy(SRT),also known as stereotactic ablative radiotherapy(SABR),includes stereotactic radiosurgery and stereotactic body radiotherapy(SBRT).This technique has the characteristics of large single fractional dose,few fractions,high equivalent biological doses,and rapid fall off-target doses.It can be implemented by relatively special equipment such as Gamma knife,Cyberknife,Tomotherapy and Vero 4D RT system,etc.In many cases,SBRT technique is employed based on linear accelerators.SRT differs from conventional radiotherapy in terms of the plan design and plan evaluation.Consequently,it is necessary to discuss the differences and provide guidance for clinical application and research.

关 键 词：立体定向放射疗法 计划设计 计划评估 

分 类 号：R730.55[医药卫生—肿瘤]