免疫球蛋白联合B族维生素对癫痫症状及生活质量的影响  

Effects of Immunoglobulin Combined with B vitamins on Epilepsy Symptoms and Quality of Life

作　　者：曹志[1] 仝秀清[1] 魏芳[1] 任彩云[1] 廖雅丽[1] CAO Zhi;TONG Xiu-qing;WEI Fang;REN Cai-yun;LIAO Ya-li(Department of Neurology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia,010059,China)

机构地区：[1]内蒙古医科大学附属医院神经内科,内蒙古呼和浩特010059

出　　处：《现代生物医学进展》2021年第3期511-514,共4页Progress in Modern Biomedicine

基　　金：内蒙古自治区卫生厅科研项目(201703097)。

摘　　要：目的:探讨免疫球蛋白联合B族维生素对癫痫症状及生活质量的影响。方法:2017年2月至2020年1月选择在本院诊治的癫痫患者78例,根据随机数字表法把患者分为观察组与对照组各39例。两组都给予常规治疗,对照组给予维生素B12治疗,观察组给予免疫球蛋白联合维生素B12治疗,记录两组治疗后症状与生活质量情况。结果:治疗后观察组的总有效率为97.4%,显著高于对照组的84.6%(P<0.05)。两组治疗期间的腹胀、嗜睡、胃痛、发热等不良反应情况对比差异无统计学意义(P>0.05)。治疗后两组的血清同型半胱氨酸(homocysteine,Hcy)含量低于治疗前,观察组也低于对照组,对比差异都有统计学意义(P<0.05)。观察组治疗后的精神健康、情感职能、社会功能、活力、总体健康、躯体疼痛、生理职能、生理功能等生活质量评分都显著高于对照组(P<0.05)。结论:免疫球蛋白联合B族维生素在癫痫患者的应用能促进改善临床症状,提高治疗效果,抑制Hcy的释放,且不增加患者不良反应的发生,从而提高生活质量。Objective: To explore the effects of immunoglobulin combined with B vitamins on epilepsy symptoms and quality of life. Methods: From February 2017 to January 2020, 78 cases of patients with epilepsy diagnosed and treated in our hospital were selected,and were divided into observation group and control group of 39 cases in each groups accorded to random number table method. Two groups were given conventional treatment, the control group was given vitamin B12 treatment, the observation group was given immunoglobulin combined with vitamin B12 treatment, and the symptoms and quality of life of the two groups after treatment were recorded.Results: The total effective rates of the observation group after treatment were 97.4 %, which was significantly higher than that of the control group(84.6 %, P<0.05). There were no statistically significant difference in adverse reactions compared between the two groups during treatment, such as abdominal distension, drowsiness, stomach pain, and fever(P>0.05). After treatment, the serum homocysteine(Hcy) content of the two groups were lower than before treatment, and the observation group were also lower than the control group, and compared the difference were statistically significant(P<0.05). The quality of life scores of the observation group after treatment were significantly higher than those of the control group in terms of quality of life such as mental health, emotional function, social function,vitality, general health, physical pain, physiological function, and physiological function(P<0.05). Conclusion: The application of immunoglobulin combined with B vitamins in patients with epilepsy can promote the improvement of clinical symptoms, improve the therapeutic effect, inhibit the release of Hcy, and do not increase the incidence of adverse reactions in patients, thereby improving the quality of life.

关 键 词：免疫球蛋白 B族维生素 癫痫 同型半胱氨酸 生活质量 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R977.22[医药卫生—临床医学]