低频脉冲电疗联合针灸对脑卒中后吞咽障碍患者吞咽功能、脑血流以及血浆一氧化氮、超氧化物歧化酶的影响  

Effects of Low Frequency Pulse Electrotherapy Combined with Acupuncture on Swallowing Function, Cerebral Blood Flow, Plasma NO and SOD in Patients with Dysphagia after Stroke

作　　者：王晓英 辛崇华 刘瑞芳 王楠 万顺伦 WANG Xiao-ying;XIN Chong-hua;LIU Rui-fang;WANG Nan;WAN Shun-lun(Department of Physiotherapy,Navy Qingdao Special Service Recuperation Center,Qingdao,Shandong,266022,China;Department of Acupuncture,Juxian Hospital of Traditional Chinese Medicine,Rizhao,Shandong,276500,China;Department of Geriatric Rehabilitation,Navy Qingdao Special Service Recuperation Center,Qingdao,Shandong,266022,China;Department of Internal Neurology,Navy 971 Hospital of the People's Liberation Army of China,Qingdao,Shandong,266071,China)

机构地区：[1]海军青岛特勤疗养中心理疗科,山东青岛266022 [2]莒县中医医院针灸科,山东日照276500 [3]海军青岛特勤疗养中心老年病康复科,山东青岛266022 [4]中国人民解放军海军971医院神经内科,山东青岛266071

出　　处：《现代生物医学进展》2021年第3期529-532,共4页Progress in Modern Biomedicine

基　　金：海军后勤部科研计划项目(CJN15L278)。

摘　　要：目的:探讨低频脉冲电疗联合针灸对脑卒中后吞咽障碍患者吞咽功能、脑血流以及血浆一氧化氮、超氧化物歧化酶的影响。方法:选取2013年3月~2019年12月期间我院收治的脑卒中后吞咽障碍患者80例,按照随机数字表法分为对照组(n=40)和研究组(n=40),对照组患者予以低频脉冲电疗,研究组在对照组基础上联合针灸治疗,比较两组患者的疗效、吞咽功能、脑血流、血浆一氧化氮、超氧化物歧化酶水平以及不良反应发生情况。结果:研究组治疗1个月后的临床总有效率为92.50%(37/40),高于对照组的72.50%(29/40)(P<0.05)。两组治疗1个月后右侧椎动脉、基底动脉、左侧椎动脉的平均血流速度均升高,且研究组高于对照组(P<0.05)。两组患者治疗1个月后一氧化氮下降,且研究组低于对照组(P<0.05);超氧化物歧化酶升高,且研究组高于对照组(P<0.05)。两组患者治疗1个月后洼田饮水试验等级均降低,且研究组低于对照组(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。结论:低频脉冲电疗联合针灸治疗脑卒中后吞咽障碍患者,可有效促进脑循环,改善患者吞咽功能,减轻机体氧化应激,疗效显著。Objective: To investigate the effect of low frequency pulse electrotherapy combined with acupuncture on swallowing function, cerebral blood flow, plasma nitric oxide, superoxide dismutase in patients with dysphagia after stroke. Methods: 80 patients with dysphagia after stroke who were admitted to our hospital from March 2013 to December 2019 were selected, they were divided into control group(n=40) and study group(n=40) according to the method of random number table. Patients in the control group were given low-frequency pulse electrotherapy. The study group was combined with acupuncture and moxibustion on the basis of the control group.The therapeutic effect, swallowing function, cerebral blood flow, plasma nitric oxide, superoxide dismutase and adverse reactions were compared between the two groups. Results: The total clinical effective rate of the study group was 92.50%(37/40), higher than 72.50%(29/40) of the control group(P<0.05). The mean blood flow velocity of left vertebral artery, right vertebral artery and basilar artery in the two groups increased after one month of treatment, and that in the study group was higher than that in the control group(P<0.05). After 1 month of treatment, the level of nitric oxide in the study group was lower than that in the control group(P<0.05), and the level of superoxide dismutase in the study group was higher than that in the control group(P<0.05). After 1 month of treatment, the grade of Wa Tian drinking water test in the two groups was lower than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Low frequency pulse electrotherapy combined with acupuncture is effective in the treatment of dysphagia after stroke, which can effectively improve the swallowing function, promote brain circulation, and reduce oxidative stress.

关 键 词：低频脉冲电疗 针灸 脑卒中 吞咽障碍 吞咽功能 脑血流 一氧化氮 超氧化物歧化酶 

分 类 号：R743[医药卫生—神经病学与精神病学] R454.1[医药卫生—临床医学]