COTE1在肝细胞癌中的表达及其与临床病理参数及预后的相关性  

The Expression of COTE1 in Hepatocellular Carcinoma and Its Correlation with Prognosis of Patients with Hepatocellular Carcinoma

作　　者：吴越 张海[1] 沙鑫[1] 陈述[1] 徐三荣[1] WU Yue;ZHANG Hai;SHA Xin;CHEN Shu;XU San-rong(Department of General Surgery,Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu,212001,China)

机构地区：[1]江苏大学附属医院普外科,江苏镇江212001

出　　处：《现代生物医学进展》2021年第3期571-575,共5页Progress in Modern Biomedicine

基　　金：江苏省社会发展基金资助项目(BE20171297)。

摘　　要：目的:探究重组人序列相似性家族189成员B(FAM189B,别名COTE1)在肝细胞癌组织中的表达及与肝细胞癌患者预后的相关性。方法:收集59例行肝细胞癌根治术的患者,取其肝细胞癌组织及癌旁组织,采用免疫组织化学法检测COTE1表达,分析COTE1表达与临床病理参数的关系,采用Kaplan-Meier生存曲线分析COTE1表达与患者预后的关系,并采用COX比例风险回归模型分析预后的影响因素。结果:免疫组织化学法检测结果显示,肝细胞癌组织中37例COTE 1高表达,癌旁组织中24例COTE1高表达,肝细胞癌组织中COTE1的表达率明显高于癌旁组织(P<0.05);COTE1表达与甲胎蛋白(AFP)值及肿瘤复发情况存在相关性(P<0.05),而与年龄、性别、肿瘤大小无关(P>0.05)。Kaplan-Meier曲线分析发现,COTE1高表达的肝细胞癌患者术后生存期较短(P<0.05)。COX比例风险回归分析发现COTE1表达可以作为影响肝细胞癌患者预后的一个独立危险因素(P<0.05)。结论:COTE1在肝细胞癌组织中表达高于癌旁组织,COTE1表达可以作为一个独立因素来预测肝细胞癌患者的预后。Objective: To explore the expression of recombinant human sequence Family with sequence similarity 189 member B(FAM189 B, its another name is COTE1) in hepatocellular carcinomaand and its correlation with prognosis of patients with hepatocellular carcinoma. Methods: 59 patients with hepatocellular carcinoma were enrolled in this study, their hepatocellular carcinoma tissues and para-carcinoma tissues were taken, the expression of COTE1 was detected by immunohistochemistry assay, the relationship between the expression of COTE1 and clinicopathological parameters was analyzed, the relationship between the expression of COTE1 and prognosis of patients was analyzed by Kaplan-meier survival curve and the influence factors of prognosis were analyzed by COX proportional hazards regression model. Results: The result of immunohistochemistry assay showed there were 37 cases among the hepatocellular carcinoma tissues had high expression of COTE1, 24 cases among the para-carcinoma tissues had high expression of COTE1, the expression percentage of COTE1 in hepatocellular carcinoma tissues was obvious higher than that in para-carcinoma tissues(P<0.05). The expression of COTE1 and alpha fetoprotein(AFP), tumor recurrence were correlative(P<0.05), but there was no correlation between the expression of COTE1 and age, gender, tumor size(P>0.05). Kaplan-meier curve analysis found that survival duration after operation of hepatocellular carcinoma patients with high expressed COTE1 was short( P <0.05). COX proportional risk regression analysis found that the expresstion of COTE1 could be an independent risk factor to affect prognosis of patients with hepatocellular carcinoma( P<0.05).Conclusion: The expression of COTE1 in hepatocellular carcinoma tissues is higher than that in para-carcinoma tissues, COTE1 expression could be an independent factor to predict prognosis of patients with hepatocellular carcinoma.

关 键 词：COTE1 肝细胞癌 临床病理特征 预后 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]