PF化疗同步联合时辰放疗与常规放疗治疗局部晚期鼻咽癌的随机对照研究  

Randomized Controlled Trial of PF Chemotherapy Combined with Chronomodulated Radiation Therapy and Conventional Radiotherapy for Locally Advanced Nasopharyngeal Carcinoma

作　　者：何淼[1] 杨桄权 游红 李超[1] 任涛 HE Miao;YANG Guang-quan;YOU Hong;LI Chao;REN Tao(Department of Oncology,Deyang people's Hospital,Deyang,Sichuan,618000,China;Department of Oncology,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan,610500,China)

机构地区：[1]德阳市人民医院肿瘤科,四川德阳618000 [2]成都医学院第一附属医院肿瘤科,四川成都610500

出　　处：《现代生物医学进展》2021年第2期342-346,共5页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研项目(1200141);德阳市科技局应用技术研究与开发项目(2017SZ074)。

摘　　要：目的:比较局部晚期鼻咽癌分别接受顺铂联合氟尿嘧啶方案(PF)化疗联合时辰放疗以及PF化疗联合常规放疗时的疗效和毒副反应。方法:将我科45例初治局部晚期鼻咽癌患者随机分为时辰放疗组和常规放疗组,分别为22例和23例。两组均采用相同放射治疗方法和治疗剂量,同步给予PF方案化疗。时辰放疗组放疗时间在20:00-22:00,而常规放疗组在8:00-10:00。结果:两组患者在放疗结束3个月和6个月进行时比较发现,时辰放疗组患者的鼻咽部及颈部的肿瘤完全消退率(CR率)均比常规放疗组高(P<0.05)。而时辰放疗组的各种急性副作用发生率较常规放疗组低,但无统计学差异。治疗后时辰组CD4/CD8升高,常规组CD4/CD8降低(P<0.05)。结论:时辰放疗联合PF同步化疗针对局部晚期鼻咽癌患者疗效好,毒副作用轻,同时可能有利于改善患者的免疫功能。Objective: Compared the efficacy and side effects of PF chemotherapy combined with chronomodulated radiation therapy and PF chemotherapy combined with conventional radiotherapy in locally advanced nasopharyngeal carcinoma. Methods: Forty-five patients with locally advanced nasopharyngeal carcinoma were randomly divided into chronomodulated radiation therapy group and conventional radiotherapy group, 22 cases and 23 cases respectively. The same radiotherapy method and therapeutic dose were used in both groups, and PF regimen was given simultaneously. The radiotherapy time of the chronomodulated radiation therapy group is between 20:00 and 22:00, while the conventional radiotherapy group is between 8:00 and 10:00. Results: At the time of 3 months and 6 months after the radiotherapy, the complete regression rate(CR rate) of the nasopharynx and neck of the patients in the chronomodulated radiation therapy group was higher than that of the conventional radiotherapy group(P<0.05). The incidence of various acute side effects in the chronomodulated radiation therapy group was lower than that in the conventional radiotherapy group, but there was no statistical difference. The level of CD4/CD8 was elevated in the chronomodulated radiation therapy group after treatment, while it was decreased in the conventional group(P<0.05). Conclusion: PF chemotherapy combined with chronomodulated radiation therapy is effective in patients with locally advanced nasopharyngeal carcinoma, with mild toxic and side effects, and may be beneficial to improve the immune function of patients.

关 键 词：鼻咽癌 时辰放疗 常规放疗 

分 类 号：R739.6[医药卫生—肿瘤]