复合式与传统小梁切除术对青光眼患者眼压、生活质量及血清细胞因子的影响  

Effect of Compound and Traditional Trabeculectomy on Intraocular Pressure,Quality of Iife and Serum Cytokines in Patients with Glaucoma

作　　者：张韫洁 李新章[1] 赵莉[1] 索南措[1] 张琼[1] ZHANG Yun-jie;LI Xin-zhang;ZHAO Li;SUO Nan-cuo;ZHANG Qiong(Department of Ophthalmology,Qinghai Red Cross Hospital,Xining,Qinghai,810000,China)

机构地区：[1]青海红十字医院眼科,青海西宁810000

出　　处：《现代生物医学进展》2021年第2期393-396,共4页Progress in Modern Biomedicine

基　　金：青海省科学技术厅应用基础研究计划项目(2015-ZJ-1173)。

摘　　要：目的:对比复合式与传统小梁切除术对青光眼患者眼压、生活质量及血清细胞因子的影响。方法:前瞻性选取2014年1月-2018年10月期间我院收治的青光眼患者80例,随机分为A组[n=38,传统小梁切除术]和B组[n=42,复合式小梁切除术],比较两组患者视力、眼压、生活质量、血清细胞因子及并发症发生情况。结果:两组患者术后1个月、术后3个月、术后6个月眼压呈不断下降趋势,且B组低于A组(P<0.05);B组术后3个月、术后6个月视力高于A组(P<0.05)。两组患者术后6个月生活质量量表(SF-36)各维度评分均升高,且B组高于A组(P<0.05)。两组患者术后1个月白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血管内皮生成因子(VEGF)均降低,且B组低于A组(P<0.05);两组患者术后1个月色素上皮衍生因子(PEDF)升高,且B组高于A组(P<0.05)。B组并发症发生率低于A组(P<0.05)。结论:与传统小梁切除术相比,复合式小梁切除术在改善青光眼患者中的视力、眼压、生活质量、血清细胞因子方面效果显著,同时还可减少并发症发生率。Objective: To compare the effects of compound trabeculectomy and traditional trabeculectomy on intraocular pressure,quality of life and serum cytokines in patients with glaucoma. Methods: The clinical data of 80 patients with glaucoma who were admitted to our hospital from January 2014 to October 2018 were selected prospectively, the patients were randomly divided into the group A[n=38, traditional trabeculectomy] and group B [n=42, compound trabeculectomy]. The visual acuity, intraocular pressure, quality of life,serum cytokines and complications condition of the two groups were compared. Results: The intraocular pressure of the two groups decreased at 1 month, 3 months and 6 months after operation, and those of group B were lower than those of group A(P<0.05). The visual acuity of group B at 3 months and 6 months after operation were higher than that of group A(P<0.05). The scores of all dimensions of the health survey scale-36(SF-36) of the two groups at 6 months after operation increased, and those of group B were higher than those of group A(P<0.05). The interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) and vascular endothelial growth factor(VEGF) were decreased in both groups at 1 month after operation, and those of group B were lower than those of group A(P<0.05). Pigment epithelium-derived factor(PEDF) was elevated in both groups at 1 month after operation, and that of group B was higher than that of group A(P<0.05). The incidence of complications in group B was lower than that in group A(P<0.05). Conclusion: Compared with traditional trabeculectomy, compound trabeculectomy is effective in improving vision, intraocular pressure, quality of life and serum cytokines in patients with glaucoma, and it can also reduce the incidence of complications.

关 键 词：复合式小梁切除术 传统小梁切除术 青光眼 眼压 生活质量 细胞因子 

分 类 号：R775[医药卫生—眼科]