AFP、血流变、超敏C反应蛋白检测在早期肝癌诊断价值分析  

Diagnostic Value of AFP, Hemorheology and High-Sensitivity C-reactive Protein in Early Liver Cancer

作　　者：杨静玲 张宁梅 王凯歌 曹婷挺 张宁 YANG Jing-ling;ZHANG Ning-mei;WANG Kai-ge;CAO Ting-ting;ZHANG Ning(Department of Clinical Laboratory,Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi'an,Shaanxi,710003,China;Department of Clinical Laboratory,Yan'an University Affiliated Hospital,Yan'an,Shaanxi,716000,China;Department of Clinical Laboratory,Xi'an West Air Hospital,Xi'an,Shaanxi,710021,China;Department of Clinical Laboratory,Weinan Psychiatric Hospital,Weinan,Shaanxi,714000,China)

机构地区：[1]陕西省中医医院检验科,陕西西安710003 [2]延安大学附属医院检验科,陕西延安716000 [3]西安市西航医院检验科,陕西西安710021 [4]渭南市精神病医院检验科,陕西渭南714000

出　　处：《现代生物医学进展》2021年第1期125-128,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81603631)。

摘　　要：目的:探讨甲胎蛋白(alphafetoprotein,AFP)、血流变、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)等指标检测对早期肝癌患者的诊断价值。方法:将我院自2016年5月至2019年5月间收治的经手术和病理学检查确诊肝癌患者115例作为A组,109例其他肝脏良性病变患者作为B组,同期体检健康者98例作为对照组C组,观察三组对象的AFP、血流变和超敏C反应蛋白等各项指标的水平。结果:A组患者的AFP水平和hs-CRP水平均明显高于B组肝脏良性病变组和C组健康对照组,B组患者AFP高于C组,组间差异具有统计学意义(P<0.05),B组和C组患者hs-CRP水平比较差异无统计学意义(P>0.05);A组患者全血高、中、低切粘度、全血粘度、红细胞压积、血细胞比容、血沉方程K值、纤维蛋白原、红细胞聚集指数和红细胞刚性指数等指标水平均明显高于B组和C组对象,B组患者血沉和血沉方程K值明显高于C组,组间差异具有统计学意义(P<0.05);A组肝癌患者TNM分期较高的患者血沉方程K值、血细胞比容、血浆粘度和全血低切粘度均明显高于TNM低分期的患者,差异具有统计学意义(P<0.05)。结论:患者的AFP、hs-CRP联合血流变血指标的异常改变可作为鉴别肝脏良性疾病和恶性肿瘤的依据,同时能提高诊断的准确性,可在临床范围内推广使用。Objective: To investigate the diagnostic value of AFP, hemorheology and high-sensitivity C-reactive protein in patients with early liver cancer. Methods: A total of 115 patients with liver cancer diagnosed by surgery and pathology from May 2016 to May2019 were enrolled as group A, 109 patients with benign liver lesions as group B, and 98 patients with physical examination at the same time. In the control group C, the levels of AFP, hemorheology and high-sensitivity C-reactive protein in the three groups were observed.Results: The AFP level and hs-CRP level in group A were significantly higher than those in group B and the healthy control group in group C. The AFP in group B was higher than that in group C. The difference between the two groups was statistically significant(P<0.05). There was no significant difference in hs-CRP levels between group B and group C(P>0.05). Group A patients had high blood,medium and low viscosity, whole blood viscosity, hematocrit, hematocrit, and sedimentation equation. The K value, fibrinogen,erythrocyte aggregation index and erythrocyte rigidity index were significantly higher than those in group B and C. The erythrocyte sedimentation rate and erythrocyte sedimentation rate in group B were significantly higher than those in group C. The difference between groups was statistically significant(P<0.05). The blood oxygenation equation K value, hematocrit, plasma viscosity and whole blood low-cut viscosity of patients with high TNM stage in group A were significantly higher than those with low TNM. The difference was statistically significant(P<0.05). Conclusion: The abnormal changes of AFP and hs-CRP combined with hemorheology can be used as a basis for the identification of benign liver diseases and malignant tumors. At the same time, the accuracy of diagnosis can be improved and can be promoted and used in clinical practice.

关 键 词：肝癌 肝脏良性疾病 AFP 血流变 超敏C反应蛋白 诊断 

分 类 号：R735.7[医药卫生—肿瘤]