高海拔地区非霍奇金淋巴瘤凝血酶原时间与低海拔地区的对比性研究  

Comparative study of non-Hodgkin lymphoma prothrombin time in high-altitude area and low-altitude area

作　　者：郭虎林 司玉玲[2] 李国权 王亮[2] 李顺延 赵成茂 Guo Hulin;Si Yuling;Li Guoquan;Wang Liang;Li Shunyan;Zhao Chengmao(Department of Oncology,the Fifth People's Hospital of Qinghai Province,Xining 810007,China;Department of Oncology and Hematology,Tianjin Fourth Central Hospital,Tianjin 300140,China;Department of Tumor Radiotherapy,Fifth People's Hospital of Qinghai Province,Xining 810007,China)

机构地区：[1]青海省第五人民医院肿瘤内科,西宁810007 [2]天津市第四中心医院肿瘤血液科,300140 [3]青海省第五人民医院肿瘤放疗一科,西宁810007

出　　处：《中国医师进修杂志》2021年第3期202-207,共6页Chinese Journal of Postgraduates of Medicine

基　　金：2017年青海省卫生计生委科研课题项目(2017-WJZD-06)。

摘　　要：目的探讨高海拔地区与低海拔地区非霍奇金淋巴瘤(NHL)化疗过程中凝血酶原时间(PT)的变化及其临床意义,了解NHL与PT的关系。方法收集2018年8月至2019年9月高海拔地区青海省第五人民医院(平均海拔2261 m)及低海拔地区天津市第四中心医院(平均海拔1.3 m)各68例NHL患者,分别与20例高海拔地区和20例低海拔地区健康体检者比较PT;根据患者分型、分期及分级[国际预后指数(IPI评分)]分组对比高低海拔地区NHL患者初诊PT;比较高低海拔地区患者化疗6个周期后的PT变化。结果低海拔地区健康体检者及NHL患者初诊PT均低于高海拔地区[(12.3±1.3)s比(13.4±1.9)s、(12.2±0.8)s比(13.7±1.1)s],差异均有统计学意义(P<0.05),同一地区NHL患者与健康体检者比较差异无统计学意义(P>0.05);高海拔与低海拔地区NHL患者不同分型、分期及分级PT比较差异均有统计学意义(t=4.611、8.202、6.893、5.345、3.121、5.397、2.838、3.720,P<0.05),同一地区NHL患者分型、分期及分级PT比较差异均无统计学意义(P>0.05);高海拔与低海拔地区NHL患者化疗前后PT比较[(13.7±1.1)s比(12.2±0.8)s、(13.4±1.4)s比(12.0±1.3)s],差异均有统计学意义(P<0.05),同一地区NHL患者化疗前后PT比较差异无统计学意义(t=1.377、-1.222,P>0.05)。结论低海拔地区NHL患者PT低于高海拔地区,与NHL患者分型、分期、分级及化疗无明显关系。Objective To investigate the changes and clinical significance of prothrombin time(PT)during chemotherapy for non-Hodgkin lymphoma(NHL)in high-altitude area and low-altitude area,and understand the relationship between NHL and PT.Methods From August 2018 to September 2019,data of 68 cases of NHL patients in the Fifth People′s Hospital of Qinghai Province in the high-altitude area(average altitude:2261 m)and the Tianjin Fourth Central Hospital in the low-altitude area(average altitude:1.3 m)were collected and compared with those of 20 subjects from health examination.The patients were divided into groups according to the NHL classification,stage and grade(international prognostic index,IPI score),the PT at initial diagnosis was compared.The PT changes before and after chemotherapy(6 cycles)were compared between high-altitude area and low-altitude area.Results The PT in healthy subjects and PT at initial diagnosis in NHL patients in low-altitude area were lower than those in high-altitude area:(12.3±1.3)s vs.(13.4±1.9)s,(12.2±0.8)s vs.(13.7±1.1)s,and there was statistical difference(P<0.05).There was no significant difference between NHL patients and healthy patients in the same area(P>0.05).In NHL patients in high-altitude area and low-altitude area,PT of different NHL classification,stage and grade were statistically significant(t=4.611,8.202,6.893,5.345,3.121,5.397,2.838 and 3.720,P<0.05).In the same altitude area,NHL classification,stage and grade of NHL patients had no significant effect on PT,and there were no statistically significant difference(P>0.05);in NHL patients,there were statistically significant differences in PT before and after chemotherapy between high-altitude area and low-altitude area:(13.7±1.1)s vs.(12.2±0.8)s,(13.4±1.4)s vs.(12.0±1.3)s,and there were statistical differences(P<0.05),and no significant changes in PT before and after chemotherapy in the same altitude area(t=1.377 and-1.222,P>0.05).Conclusions PT of NHL patients in low-altitude area is lower than that in high-altitude

关 键 词：淋巴瘤 非霍奇金 凝血酶原时间 海拔 

分 类 号：R733.1[医药卫生—肿瘤]