手性吡啶单(口恶)唑啉配体在不对称催化反应中的研究进展  

Progress of Chiral Pyridine Monooxazoline Ligands in Asymmetric Catalytic Reactions

作　　者：张文杰 曹国锐[1] ZHANG Wen-jie;CAO Guo-rui(College of Chemistry Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]青岛科技大学化工学院,山东青岛266042

出　　处：《化学试剂》2021年第3期296-303,共8页Chemical Reagents

摘　　要：手性吡啶单唑啉配体是一类双氮配体,易与钯、铑、铱等多种金属配位,具有结构简单、价格低廉的优点。手性吡啶单唑啉配体中的吡啶环以及唑啉环上均具有丰富的修饰位点,可协调配体与底物之间的适应性,使反应更加快捷高效,在不对称催化领域涌现出丰富的科研成果。综述了近20多年关于手性吡啶单唑啉配体在共轭加成反应、Heck偶联反应、Aza-Wacker反应、C—H官能团化反应等不对称催化反应中的应用,并对手性吡啶单唑啉配体的应用前景进行了展望。Chiral pyridine monoxazoline ligands are a kind of diazo coordination ligands,which tend to complex with palladium,rhodium,iridium and other metals,and have the advantages of simple structure and low price.Both the pyridine ring and the oxazoline ring in the chiral pyridine monooxazoline ligand have abundant modification sites,which can coordinate the adaptability between the ligand and the substrate,making the reaction faster and more efficient.And rich scientific research achievements have emerged in the field of asymmetric catalysis.The applications of chiral pyridine monoxazoline ligands in asymmetric catalytic reactions such as conjugated addition reaction,Heck coupling reaction,Aza-Wacker reaction and C—H functionalization reaction were reviewed in the past 20 years,and the application prospect of chiral pyridine monoxazoline ligands is prospected.

关 键 词：吡啶单(口恶)唑啉配体 共轭加成反应 HECK偶联反应 Aza-Wacker反应 C—H官能团化反应 手性 

分 类 号：O621.1[理学—有机化学]