基于中西医临床病症特点的慢性萎缩性胃炎动物模型分析  

Analysis of animal models of chronic atrophic gastritis based on characteristics of clinical symptoms of traditional Chinese and Western medicine

作　　者：留甜甜 宋亚刚 田硕[1] 苗明三[1] LIU Tian-tian;SONG Ya-gang;TIAN Shuo;MIAO Ming-san(College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046

出　　处：《中国中药杂志》2021年第4期777-781,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81274154);中原学者项目(162101510003);国家国际合作基地项目(2016-65)。

摘　　要：基于慢性萎缩性胃炎的中西医临床病证特点,通过查阅国内外与慢性萎缩性胃炎动物模型相关文献报道,根据中西医临床各项诊断指标,整理总结慢性萎缩性胃炎评价标准,对现有慢性萎缩性胃炎动物模型的临床症状吻合度进行评价分析。统计结果发现,现有慢性萎缩性动物模型与临床吻合度较高的造模法有病证结合造模法、手术造模法、多因素综合造模法和MNNG造模法,其动物模型虽然采用了许多与人类近似的病因、发病机制以及病证结合的方法进行复制,但与自然发病状态相比仍存在较大差距,在临床上仍需进一步深入研究完善,望对慢性萎缩性胃炎临床及实验研究提供参考。Based on the clinical characteristics of chronic atrophic gastritis in traditional Chinese and Western medicine, the domestic and foreign relevant literature reports and animal models of chronic atrophic as well as the clinical diagnostic indicators of traditional Chinese and western medicine, chronic atrophic gastritis evaluation standard was summarized to evaluate and analyze the coincidence degree of clinical symptoms of the existing chronic atrophic gastritis animal models. The statistical results found that modeling methods with a higher coincidence degree with the existing chronic atrophic gastritis animal models are disease and syndrome combination mode-ling, surgical modeling, multifactor comprehensive modeling and MNNG modeling. Although the animal models were reproduced by such methods as etiology, pathogenesis and disease and syndrome combination similar to those of human beings, there is still a big gap with the natural disease state. Further in-depth studies and improvement shall be made in clinical practice in the hope to provide refe-rence for clinical practice and experimental studies of chronic atrophic gastritis.

关 键 词：慢性萎缩性胃炎 临床病症 动物模型 中西医 

分 类 号：R573.32[医药卫生—消化系统] R-332[医药卫生—内科学]