Conditional Genome Editing in the Mammalian Brain Using CRISPR-Cas9  

作　　者：Haojie Sun Jie Zheng Ming Yi You Wan 

机构地区：[1]Neuroscience Research Institute,Department of Neurobiology,School of Basic Medical Sciences,Peking University,Beijing 100083,China [2]Key Laboratory for Neuroscience,Ministry of Education/National Health Commission of China,Peking University,Beijing 100083,China [3]Department of Pathophysiology,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Neuroscience Bulletin》2021年第3期423-426,共4页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(81974166,31872774,31371119,91732107,and 81821092);Beijing Natural Science Foundation(7202083,5182013);the National Basic Research(973)Program of the Ministry of Science and Technology of China(2014CB548200 and 2015CB554503);the Interdisciplinary Medicine Seed Fund of Peking University(BMU2018MX011)。

摘　　要：Neuronal ensembles with distinct morphological,biochemical,and functional identities are organized into complex circuits in the mammalian brain,and malfunction of specific neuronal types in different networks contributes to diverse pathological symptoms.Taking memory as an example,specific memories are held in a subset of neurons,referred to as engram cells.

关 键 词：MAMMALIAN networks ORGANIZED 

分 类 号：Q78[生物学—分子生物学]