MAMMALIAN

作品数：306被引量：1205H指数：13
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相关领域：生物学更多>>
相关作者：刘冬陈溪萍刘冉陶陆阳梁蜀龙更多>>
相关机构：北京大学加利福尼亚大学首都医科大学附属北京安贞医院苏州大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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AUTS2 expression within mammalian lineage: A predictor of neural networks involved in autism spectrum disorders
《Genes & Diseases》2025年第3期11-14,共4页Aude-Marie Lepagnol-Bestel Yann Loe-Mie Mounia Bensaid Michel Simonneau 
founded by SFR Cap Santé,Universitéde Reims Champagne-Ardenne,Reims,France to Aude-Marie Lepagnol-Bestel,a European Grant ERA-Net Cofund Action on Nanomedicine under Horizon 2020 Euronanomed 3(project MoDiaNo);CNES(Centre National d'Etudes Spatiales)grant(MemoBion)to Michel Simonneau.
The autism susceptibility candidate 2(AUTS2)gene1,2 at 7q11.2 was first identified and found disrupted because of a balanced translocation in a pair of monozygotic twins with autism spectrum disorder(ASD).Analysis of ...
关键词：balanced translocation auts novel cases autism spectrum disorders autism spectrum disorder asd analysis clinical phenotypes monozygotic twins intellectual disability 
Molecular basis for shifted receptor recognition by an encephalitic arbovirus
《四川生理科学杂志》2025年第4期722-722,共1页Xiaoyi Fan 
Western equine encephalitis virus(WEEV)is an arbovirus that historically caused large outbreaks of encephalitis throughout the Americas.WEEV binds protocadherin 10(PCDH10)as a receptor,and highly virulent ancestral WE...
关键词：Cryoelectron microscopy Ldlr related proteins Western equine encephalitis virus Receptor recognition ARBOVIRUS mammalian receptors 
From mice to humans:a need for comparable results in mammalian neuroplasticity
《Neural Regeneration Research》2025年第2期464-466,共3页Marco Ghibaudi Enrica Boda Luca Bonfanti 
supported by Progetto Trapezio,Compagnia di San Paolo(67935-2021.2174)to LB,Fondazione CRT(Cassa di Risparmio di Torino,RF=2022.0618)to LB。
Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall...
关键词：PLASTICITY al. ARREST 
Molecular architecture of mammalian pyruvate dehydrogenase complex
《Protein & Cell》2025年第1期72-78,共7页Maofei Chen Yutong Song Sensen Zhang Yitang Zhang Xudong Chen Minghui Zhang Meng Han Xin Gao Sai Li Maojun Yang 
supported by the National Key R&D Program of China(2022YFA1302701);the National Natural Science Foundation of China(32030056 to M.Y.;32241031 and 32171195 to S.L.);the scientific project of Beijing Life Science Academy(2023300CA0090);Tsinghua University Initiative Scientific Research Program(2023Z11DSZ001);the King Abdullah University of Science and Technology(KAUST)Office of Sponsored Research(OSR)under Award(OSR-2020-CRG9-4352);Office of Research Administration(ORA)under Award No.URF/1/4352-01-01,FCC/1/1976-44-01,FCC/1/1976-45-01,REI/1/5234-01-01,and REI/1/5414-01-01.
Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), an...
关键词：sequentially OXIDATIVE DALTON 
Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs
《Science China Earth Sciences》2025年第1期62-73,共12页Xin LI Yibo ZHOU Tao ZHAO Xingjian HE Yanhong PAN 
supported by the National Natural Science Foundation of China(Grant Nos.42288201&41922011);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB26000000);the Fundamental Research Funds for the Central Universities(Grant No.0206-14380219)。
Mammalian hair,as a key feature related to endothermy,physical protection,and camouflage,has a long geohistorical record that dates back even to the Mesozoic.However,the limited information on the taphonomy of hair hi...
关键词：Mammalian hair MELANIN KERATIN FOSSILIZATION Experimental taphonomy 
The single-cell transcriptomic landscape of the topological differences in mammalian auditory receptors
《Science China(Life Sciences)》2024年第11期2398-2410,共13页Xiangyu Ma Xin Chen Yuwei Che Siyao Zhu Xinlin Wang Shan Gao Jiheng Wu Fanliang Kong Cheng Cheng Yunhao Wu Jiamin Guo Jieyu Qi Renjie Chai 
supported by funds from the National Key R&D Program of China(2021YFA1101300,2021YFA1101800,2020YFA012503,2020YFA0113600,2019YFA0111400);the STI2030-Major Projects(2022ZD0205400);the China Ministry of Science and Technology Grant(2021ZD0203304);the National Natural Science Foundation of China(82330033,82101236,82171149,82030029,82201286,81970882,82371162,U23A200440,92149304);the Natural Science Foundation of Jiangsu Province(BE2019711,BK20232007);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB697);the China Postdoctoral Science Foundation(2021T140113);the Shenzhen Fundamental Research Program(JCYJ20190814093401920,20210324125608022);the 2022 Open Project Fund of Guangdong Academy of Medical Sciences(YKY-KF202201);the Fundamental Research Funds for the Central Universities(2242021R20050).
Mammalian hair cells(HCs)are arranged spirally along the cochlear axis and correspond to different frequency ranges.Serving as primary sound detectors,HCs spatially segregate component frequencies into a topographical...
关键词：tonotopic axis hair cell auditory receptor scRNA-seq 
Versatile and efficient mammalian genome editing with Type Ⅰ-C CRISPR System of Desulfovibrio vulgaris被引量：1
《Science China(Life Sciences)》2024年第11期2471-2487,共17页Pan Li Dingcai Dong Fei Gao Yuyang Xie Honglin Huang Siwei Sun Zhao Ma Cheng He Jinsheng Lai Xuguang Du Sen Wu 
funded by the National Key R&D Program of China(2021YFA0805900,2023YFF1000200,2023YFF1000900,and 2023YFC3402004);the China Postdoctoral Science Foundation(2021M703521).
CRISPR-Cas tools for mammalian genome editing typically rely on single Cas9 or Cas12a proteins.While type I CRISPR systems in Class I may offer greater specificity and versatility,they are not well-developed for genom...
关键词：type I CRISPR systems Desulfovibrio vulgaris Dvu type I-C editor define deletion large fragment replacement base editing 
A breath of fresh air:targeted non-viral in vivo gene correction in the mammalian lung
《Signal Transduction and Targeted Therapy》2024年第11期4771-4772,共2页Jixin Liu Dirk Grimm 
D.G.appreciates support by the German Research Foundation(DFG)through the DFG Collaborative Research Centers SFB1129(Projektnummer 240245660);TRR179(Projektnummer 272983813).
In a recent study published in Science,1 Sun and colleagues showcase the power and potential of lung SORT LNPs,i.e.,lipid nanoparticles that upon systemic delivery in mice specifically and efficiently target cells in ...
关键词：LUNG CORRECTION EDITOR 
Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development
《Journal of Animal Science and Biotechnology》2024年第4期1528-1549,共22页Rosane Mazzarella Karina Canon‑Beltran Yulia N.Cajas Meriem Hamdi Encina M.Gonzalez Juliano C.da Silveira Claudia L.V.Leal D.Rizos 
PID2019-111641RB-I00 funded by MCIN/AEI/10.13039/501100011033/to DR and PRE2020-094452 to RM;FAPESP;#2017/20339–3 and CNPq-Brazil (304276/2018–9) to CLVL and FAPESP#2014/22887–0 and 2015/21829–9 to JCS;funded by S?o Paulo Research Foundation,Brazil;supported by a Maria Zambrano contract,and YNC for a Margarita Salas contract,both funded by the European Union–Next Generation EU program。
Background Extracellular vesicles(EVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism...
关键词：Embryo-maternal interaction EPIGENETIC Exosomes MAMMALIAN PREIMPLANTATION Reproductive fluids 
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
《四川生理科学杂志》2024年第7期1635-1635,共1页Anissa A Widjaja 
For healthspan and lifespan,ERK,AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1-7.Here we examined whether IL-11,a pro-inflammatory cytokine of the IL-6 family,has a neg...
关键词：INFLAMMATION mTORC1 life 
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