supported by grants from the National Key Research and Development Program(No.2021YFC2700604);General Program of National Natural Science Foundation of China(No.82171648);Shandong Provincial Key Research and Development Program(No.2021LCZX02);Youth Program of National Natural Science Foundation of China(No.82101752);Youth Program of Shandong Provincial Natural Science Foundation of China(No.ZR2021QH075);Taishan Scholars Program for Young Experts of Shandong Province(No.tsqn202312388);the Shandong Provincial Medical and Health Science and Technology Development Program(No.2019WS171);the Shandong Provincial Natural Science Foundation(No.ZR2020MH072).
To the Editor:Recurrent pregnancy loss(RPL)is defined as two or more consecutive spontaneous pregnancy losses before 24 weeks of gestation;it affects 1-2%of couples.[1]Some causes of RPL are uterine anatomical abnorma...
PID2019-111641RB-I00 funded by MCIN/AEI/10.13039/501100011033/to DR and PRE2020-094452 to RM;FAPESP;#2017/20339–3 and CNPq-Brazil (304276/2018–9) to CLVL and FAPESP#2014/22887–0 and 2015/21829–9 to JCS;funded by S?o Paulo Research Foundation,Brazil;supported by a Maria Zambrano contract,and YNC for a Margarita Salas contract,both funded by the European Union–Next Generation EU program。
Background Extracellular vesicles(EVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism...
supported by the research grants from the subproject of the China's National Key Research and Development Program(No.2021YFC2701002,2022YFC2703700,2022YFC2703702);the National Natural Science Foundation of China(No.81971344,82171677,82192864,82088102,81901495);the Shanghai Municipal Commission of Science and Technology Program(China)(No.22S31901500,21Y21901002,23ZR1408000);Shanghai Municipal Health Commission(No.GW-10.1-XK07);Shanghai Municipal Commission of Health and Family Planning(China)(No.202140110);CAMS Innovation Fund for Medical Sciences(No.2019-12M-5-064);Collaborative Innovation Program of Shanghai Municipal Health Commission(China)(No.2020CXJQ01);Clinical Research Plan of SHDC(China)(No.SHDC2020CR1008A);Shanghai Clinical Research Center for Gynecological Diseases(China)(No.22MC1940200);Shanghai Urogenital System Diseases Research Center(China)(No.2022ZZ01012);Shanghai Frontiers Science Research Center of Reproduction and Development(China).
Preimplantation genetic testing(PGT)is a precise and effective technique for detecting inherited pathogenic mutations to prevent birth defects.However,there are few reports on PGT for pseudo-autosomal genetic diseases.
support from ICMR-National Institute for Research in Reproductive Health(ICMR-NIRRH).
Rationale:If one of the partners is having balanced autosomal translocation,it is usually observed that the offspring inherit either normal chromosomes,balanced translocation identical to one of the parent or unbalanc...
The dynamic changes in lipids during early embryonic development in mammals have not yet been comprehensively investigated.In a recent paper published in Nature Cell Biology,Zhang et al.reported the dynamic lipid land...
This study was funded by Key R&D Program of Shandong Province(2021LCZX02);National Key Research and Development Program(2021YFC2700604,2022YFC2703202);General Program of National Natural Science Foundation of China(82171648);Taishan Scholars Program for Young Experts of Shandong Province(tsqn201812154);Youth Program of National Natural Science Foundation of China(82101752);Youth Program of Shandong Provincial Natural Science Foundation of China(ZR2021QH075);General Program of Shandong Provincial Natural Science Foundation of China(ZR2022MH087) for data fee(scientific research informed consent,etc.),paper modification,and publication fee,etc.
Objective:Although consensus on the optimal endometrial preparation protocol for frozen-thawed embryo transfer(FET)is lacking,this is particularly true for patients with infertility and a history of endometrial polyps...
supported by grants from the National Natural Science Found of China(No.81270750);Natural Science Found of Guangdong China(No.2019A1515011845);Stem Cell Research Founding from Chinese Medical Association(No.19020010780);Sun Yat-sen University 5010 Clinical Research Project(No.2023003).
Background:The goal of the assisted reproductive treatment is to transfer one euploid blastocyst and to help infertile women giving birth one healthy neonate.Some algorithms have been used to assess the ploidy status ...
Preimplantation genetic testing(PGT),which was developed as an alternative to prenatal genetic testing,allows couples to avoid pregnancies with abnormal chromosomes and the subsequent termination of the affected fetus...
supported under grants from the National Natural Science Foundation of China(22006103);Key-Area Research and Development Program of Guangdong Province(2023B1111020006)
Embryo quality is a critical determinant of clinical outcomes in assisted reproductive technology(ART).A recent clinical trial investigating preimplantation DNA methylation screening(PIMS)revealed that whole genome DN...
Purpose: We aimed to analyze the pregnancy outcomes and perinatal follow-up of mosaic embryo transfer in the preimplantation genetic testing (PGT) cycles. Method: We retrospectively selected 27 mosaic embryo transfer ...