笑气滥用患者的脑血流灌注显像  

Cerebral blood flow perfusion imaging in patients with laughing gas abuse

作　　者：尹立杰[1] 富丽萍 金超岭 汪仁斌[2] 铁常乐 王丽 郑玉民[1] Yin Lijie;Fu Liping;Jin Chaoling;Wang Renbin;Tie Changle;Wang Li;Zheng Yumin(Department of Nuclear Medicine,China-Japan Friendship Hospital,Beijing 100029,China;Department of Neurology,China-Japan Friendship Hospital,Beijing 100029,China;Department of Neurology,the First Hospital of Tsinghua University,Beijing 100016,China)

机构地区：[1]中日友好医院核医学科,北京100029 [2]中日友好医院神经内科,北京100029 [3]清华大学第一附属医院神经内科,北京100016

出　　处：《中华核医学与分子影像杂志》2021年第3期136-139,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的探讨N2O(笑气)滥用所致脑血流量(CBF)的改变。方法回顾性分析2017年12月至2018年10月间于中日友好医院就诊的24例笑气滥用患者[男9例,女15例,年龄18~32(24.0±8.9)岁]脑血流灌注显像图,计算各脑区(基底节、脑中央区、小脑、扣带回、额叶、内侧颞叶、枕叶、顶叶、颞叶)与后台软件数据库的同年龄段正常人相应感兴趣区(ROI)摄取的差异统计值。差异统计值>1.68为局部脑血流灌注升高;<-1.68为局部脑血流灌注减低。各脑区左、右双侧差异统计值的相关性采用Pearson相关分析,差异统计值与临床各指标相关性采用Spearman相关分析。结果各脑区左、右两侧差异统计值均有相关性(r值:0.503~0.892,均P<0.05)。额叶、颞叶CBF降低比例较高,分别为62.5%(15/24)及70.8%(17/24);扣带回CBF增加比例较高(33.3%,8/24)。额叶(rs=0.375)、脑中央区(rs=0.305)与笑气滥用时长有相关性(均P<0.05)。结论脑血流灌注显像有助于了解笑气滥用患者脑血流变化情况。Objective To explore the changes of cerebral blood flow(CBF)perfusion caused by N2O(laughing gas)abuse.Methods From December 2017 to October 2018,the CBF perfusion images of 24 patients with laughing gas abuse(9 males,15 females;age:18-32(24.0±8.9)years)from China-Japan Friendship Hospital were analyzed retrospectively.The region uptake statistics of different brain regions of interest(ROI)(basal ganglia,central region,cerebellum,cingulate gyrus,frontal lobe,medial temporal lobe,occipital lobe,parietal lobe,temporal lobe)between patients with laughing gas abuse and normal people of the same age group from background software database were calculated automatically.Statistic>1.68 indicated the increase of local CBF perfusion,while statistic<-1.68 indicated the decrease of local CBF perfusion.The correlation between the statistics of bilateral brain regions and the correlation between statistical values and clinical indicators were analyzed by Pearson and Spearman correlation analyses.Results The correlation of the statistics between bilateral regions of each brain area was significant(r values:0.503-0.892,all P<0.05).The decreased CBF proportions of frontal and temporal lobes were 62.5%(15/24)and 70.8%(17/24),respectively.The highest proportion of increased CBF was cingulate gyrus(33.3%,8/24).There were significant correlations between frontal lobe,central brain area and duration of laughing gas abuse(rs values:0.375,0.305,both P<0.05).Conclusion CBF perfusion imaging is helpful for understanding the changes of CBF in patients with laughing gas abuse.

关 键 词：氧化亚氮 脑血管循环 体层摄影术 发射型计算机 单光子 锝 半胱氨酸 

分 类 号：R749.6[医药卫生—神经病学与精神病学]