BPL重建技术对^(18)F-FDG PET/CT正常组织的代谢参数及图像质量的影响  

Impact of Bayesian penalized likelihood algorithm on the metabolism parameters and image quality in ^(18)F-FDG PET/CT background tissues

作　　者：林乐军[1] 王永涛[1] 姚小芹 吕晓宁 李金玉 李善春[1] Lin Lejun;Wang Yongtao;Yao Xiaoqin;Lyu Xiaoning;Li Jinyu;Li Shanchun(Department of Nuclear Medicine,Yuhuangding Hospital,Yantai 264100,China)

机构地区：[1]烟台毓璜顶医院核医学科,264100

出　　处：《中华核医学与分子影像杂志》2021年第3期155-160,共6页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的探讨贝叶斯正则化似然(BPL)重建技术对18F-脱氧葡萄糖(FDG)PET/CT正常组织代谢参数及图像质量的影响。方法回顾性分析2019年3月至2019年6月间烟台毓璜顶医院60例肿瘤患者[男29例,女31例,年龄24~89(60.4±15.2)岁]的PET/CT体部检查数据,将PET图像按照有序子集最大期望值迭代法(OSEM)、飞行时间(TOF)+点扩散函数(PSF)和BPL(β值=350)3种重建技术进行重建,分别于右肺上叶、肝脏右后叶、主动脉根部和腰椎勾画感兴趣体积(VOI),测量VOI代谢参数[包括平均标准摄取值(SUVmean)、最大标准摄取值(SU_(Vmax))、瘦体质量标准摄取值(SUV)峰值(SU_(Lpeak))、SUV标准差(SUVSD)],并计算信噪比(SNR),分析SNR变化率(%ΔSNR)与体质指数(BMI)的关系。采用单因素方差分析、最小显著差异t检验和Pearson相关分析数据。结果3种重建技术的正常肺、主动脉、肝脏及腰椎的SUVmean及SU_(Lpeak)差异均无统计学意义(F值:0.04~1.95,均P>0.05)。BPL组正常肺、主动脉、肝脏和腰椎的SU_(Vmax)(1.14±0.82、2.13±0.37、2.95±0.50和2.76±0.87)较TOF+PSF组(1.56±0.61、2.99±0.75、4.32±0.94和4.05±1.48)和OSEM组(1.51±0.67、3.00±0.70、4.45±1.12和3.81±1.06)明显降低(F值:20.59~52.24,均P<0.001);SUVSD(0.13±0.07、0.20±0.05、0.26±0.06和0.38±0.17)较TOF+PSF组(0.24±0.11、0.43±0.11、0.58±0.15和0.67±0.21)和OSEM组(0.21±0.09、0.42±0.10、0.58±0.14和0.63±0.20)也明显降低(F值:24.46~124.95,均P<0.001);而SNR(4.67±1.34、7.74±2.22、8.17±1.77和4.45±1.22)则明显高于TOF+PSF组(2.54±0.72、3.55±0.82、3.77±0.91和2.49±0.69)和OSEM组(2.65±0.64、3.67±0.80、3.75±0.87和2.60±0.67;F值:83.04~247.73,均P<0.001);而TOF+PSF组与OSEM组间比较,代谢参数、SUVSD和SNR差异均无统计学意义(均P>0.05)。BPL重建组SNR随着BMI的增加而增加,且BMI<25 kg/m2和BMI≥30 kg/m2组之间主动脉SNR(7.07±2.21和9.67±2.26)和肝脏SNR(7.75±1.85和9.32±0.70)差异有统计学意义(F值:3.46、4.19,均Objective To investigate the impact of Bayesian penalized likelihood(BPL)PET reconstruction method on the uptake of 18F-fluorodeoxyglucose(FDG)and signal to noise ratio(SNR)of lungs,liver,aorta and bones.Methods From March 2019 to June 2019,the 18F-FDG PET/CT images of 60 patients with clinical diagnosed tumors(29 males,31 females,age:24-89(60.4±15.2)years)in Yuhuangding Hospital were retrospectively analyzed.PET images were reconstructed with ordered subset expectation maximization(OSEM),time of flight(TOF)+point spread function(PSF)and BPL(β=350)algorithms.Volumes of interest(VOIs)were delineated on the right upper lung lobe,the right liver,aortic root and lumbar vertebra.The mean standardized uptake value(SUVmean),maximum standardized uptake value(SU_(Vmax)),peak of lean body standardized uptake value(SU_(Lpeak)),standard deviation of standardized uptake value(SUVSD)and the SNR were measured.The percentage of SNR change(%ΔSNR)between the BPL method and non-BPL methods were calculated.The correlations between body mass index(BMI)and%ΔSNR were analyzed by Pearson correlation analysis.One-way analysis of variance and the least significant difference(LSD)t test were used to analyze the data.Results There were no significant differences of SUVmean and SU_(Lpeak) in lung,aorta,liver and lumbar vertebra among 3 methods(F values:0.04-1.95,all P>0.05).The SU_(Vmax) in lung,aorta,liver and lumbar vertebra of BPL reconstruction(1.14±0.82,2.13±0.37,2.95±0.50 and 2.76±0.87)was significantly lower than those of TOF+PSF(1.56±0.61,2.99±0.75,4.32±0.94 and 4.05±1.48)and OSEM(1.51±0.67,3.00±0.70,4.45±1.12 and 3.81±1.06)reconstructions(F values:20.59-52.24,all P<0.001)and SUVSD(0.13±0.07,0.20±0.05,0.26±0.06,0.38±0.17)was also significantly lower than those of TOF+PSF(0.24±0.11,0.43±0.11,0.58±0.15,0.67±0.21)and OSEM(0.21±0.09,0.42±0.10,0.58±0.14,0.63±0.20)reconstructions(F values:24.46-124.95,all P<0.001),while the SNR(4.67±1.34,7.74±2.22,8.17±1.77,4.45±1.22)was significantly higher than those of TO

关 键 词：正电子发射断层显像术 体层摄影术 X线计算机 图像处理 计算机辅助 贝叶斯定理 脱氧葡萄糖 

分 类 号：R730.44[医药卫生—肿瘤]