放射性核素标记的成纤维细胞激活蛋白靶向分子探针的研究进展  

Research progress of radionuclide labeled fibroblast activation protein targeted molecular probes

作　　者：谈健伶 兰晓莉[1] 张永学[1] Tan Jianling;Lan Xiaoli;Zhang Yongxue(Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province Key Laboratory of Molecular Imaging,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科、分子影像湖北省重点实验室,武汉430022

出　　处：《中华核医学与分子影像杂志》2021年第3期180-184,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(81771863)。

摘　　要：成纤维细胞激活蛋白(FAP)是癌症相关成纤维细胞(CAFs)的标志性蛋白,在90%以上的上皮癌中有高表达,而正常组织几乎不表达。因此,FAP是一个非常有潜力的靶点。放射性核素标记的FAP靶向分子探针可用于PET或SPECT显像,尤其是68Ga-FAP抑制剂(FAPIs)PET/CT在临床上已显示出良好的前景,为肿瘤的早期诊断、精确分期以及放射性核素治疗提供了一种新的思路。此外,FAP在某些非肿瘤疾病也有高表达,尤其是与纤维化相关的疾病。该文将对放射性核素标记的靶向FAP分子探针的研究进展做一综述。Fibroblast activation protein(FAP)is a marker protein of cancer-associated fibroblasts(CAFs).It is highly expressed in more than 90%of epithelial cancers and hardly expressed in normal tissues.Therefore,FAP is a very promising target.Radionuclide labeled FAP targeted molecular probes can be used for PET or SPECT imaging.In particular,68Ga-FAP inhibitors(FAPIs)PET/CT has shown good prospects in the clinic,providing a new idea for early diagnosis,accurate staging and radionuclide treatment of tumors.In addition,FAP is also highly expressed in certain non-tumor diseases,especially those related to fibrosis.In this article,the research progress of radionuclide-labeled FAP targeted molecular probes is reviewed.

关 键 词：成纤维细胞 拮抗剂和抑制剂 同位素标记 发展趋势 

分 类 号：R730.2[医药卫生—肿瘤]