新辅助化疗联合放疗对宫颈癌患者临床疗效及预后的影响  

Effect of neoadjuvant chemotherapy combined with radiotherapy on the clinical efficacy and prognosis of patients with cervical cancer

作　　者：王朋丽[1] 牛海燕 宋云焕[1] 李晓茹[1] WANG Pengli;NIU Haiyan;SONG Yunhuan;LI Xiaoru(Department of Obstetrics and Gynecology,Zhengzhou First People’s Hospital,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州市第一人民医院妇产科,郑州4500000

出　　处：《癌症进展》2021年第5期522-524,共3页Oncology Progress

摘　　要：目的探讨新辅助化疗联合放疗对宫颈癌患者临床疗效及预后的影响。方法根据治疗方式的不同将85例宫颈癌患者分为单独放疗组(行放疗)37例和联合治疗组(行新辅助化疗联合放疗)48例。比较两组患者治疗后的临床疗效、肿瘤直径及不良反应发生情况。对两组患者均随访2年,比较两组患者的复发率、生存率。结果治疗后,联合治疗组患者的总有效率高于单独放疗组患者(P﹤0.05)。治疗后,联合治疗组患者的肿瘤直径明显短于单独放疗组,差异有统计学意义(P﹤0.01)。截至随访结束,单独放疗组患者的复发率高于联合治疗组患者,生存率低于联合治疗组患者(P﹤0.05)。单独放疗组患者放射性直肠炎、放射性膀胱炎的发生率均高于联合治疗组患者(P﹤0.05)。结论新辅助化疗联合放疗可有效提高宫颈癌患者的临床疗效,提高生存率,降低复发率,且不良反应可控。Objective To investigate the effect of neoadjuvant chemotherapy combined with radiotherapy on the clinical efficacy and prognosis of patients with cervical cancer.Method According to different treatment regimens,85 patients with cervical cancer were divided into radiotherapy alone group(receiving radiotherapy)with 37 cases and combined treatment group(receiving neoadjuvant chemotherapy combined with radiotherapy)with 48 cases.The clinical efficacy,tumor size and occurrence of adverse reactions were compared between the two groups after treatment.Both groups of patients were followed up for 2 years,and the rate of recurrence and survival of the two groups of patients were compared.Result After treatment,the combined treatment group’s total effective rate was higher than that of the radiotherapy alone group(P<0.05).After treatment,the combined treatment group’s tumor diameter was significantly shorter than that of the radiotherapy alone group(P<0.01).The patients were followed up for two years after treatment,and the recurrence rate of patients in the radiotherapy alone group was higher than that of the combined treatment group,the survival rate of patients in the radiotherapy alone group was lower than that in the combined treatment grou(P<0.05).The incidence rate of radiation proctitis and cystitis in the radiotherapy alone group was higher than that in the combined treatment group(P<0.05).Conclusion Neoadjuvant chemotherapy combined with radiotherapy can effectively strengthen the clinical effect,prolong survival,reduce the recurrence rate with controllable adverse reactions.

关 键 词：新辅助化疗 放疗 宫颈癌 临床疗效 生存 不良反应 

分 类 号：R737.33[医药卫生—肿瘤]