EB病毒编码的microRNAs参与肿瘤的发生和发展  

Epstein-Barr virus-encoded microRNAs involve in tumorigenesis and development

作　　者：李巍明 易伟宏 杨大志 李桂源[2] LIWeiming;YIWeihong;YANG Dazhi;LI Guiyuan(Department of Orthopedics,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen Guangdong 518000;Institute of Cancer Research,Central South University,Changsha 410078,China)

机构地区：[1]华中科技大学协和深圳医院骨科,广东深圳518000 [2]中南大学肿瘤研究所,长沙410078

出　　处：《中南大学学报（医学版）》2021年第3期300-308,共9页Journal of Central South University ：Medical Science

基　　金：深圳市南山区科技创新局教育(卫生)科技资助项目(2018005)。

摘　　要：EB病毒(Epstein-Barr virus,EBV)是一种明确的致瘤性病毒,与鼻咽癌、胃癌、淋巴瘤等多种肿瘤的发生和发展密切相关。EBV共编码44种成熟的微RNA(microRNAs,miRNAs),可调节病毒自身和宿主基因的表达。EBV编码的miRNAs(Epstein-Barr virus-encoded microRNAs,EBV miRNAs)及其所调控的靶分子参与肿瘤细胞的凋亡、增殖、侵袭和转移等方面的生物学功能,在肿瘤发生和发展过程中发挥重要作用。Epstein-Barr virus(EBV),a definite tumorigenic virus,is closely related to the development of nasopharyngeal cancer,gastric cancer,lymphoma and other tumors.EBV encodes a total of 44 mature microRNAs,which can regulate the expression of virus and host genes.EBV-encoded microRNAs and their regulated target molecules participate in the biological functions of tumor apoptosis,proliferation,invasion,and metastasis during tumorigenesis and development,and play an important role in the development of tumor.

关 键 词：EB病毒编码的microRNAs 潜伏感染 肿瘤 上皮间质转化 

分 类 号：R730.2[医药卫生—肿瘤]