单核细胞显著增加的初诊慢性粒细胞白血病伴罕见核型1例及文献复习  

Chronic myeloid leukemia with a significant increase of monocytes and rare karyotype:A case report and literature review

作　　者：张颖[1] 谭倩[1] 曹鹏飞[1] 陈聪 陈伟[2] ZHANG Ying;TAN Qian;CAO Pengfei;CHEN Cong;CHENWei(Department of Hematology,Xiangya Hospital,Central South University,Changsha 410008;Department of Gastroenterology,Changsha Central Hospital,Changsha 410004,China)

机构地区：[1]中南大学湘雅医院血液科,长沙410008 [2]长沙市中心医院消化内科,长沙410004

出　　处：《中南大学学报（医学版）》2021年第3期322-327,共6页Journal of Central South University ：Medical Science

摘　　要：单核细胞增加的慢性粒细胞白血病临床少见,与慢性粒-单核细胞白血病难以鉴别。1例31岁男性患者,以全身疼痛起病,初步诊断为慢性粒单核细胞白血病,经融合基因和染色体等检查最终确诊为慢性粒细胞白血病。除了典型的Ph染色体外,还发现罕见的染色体易位t(2;7)(p13;p22)。流式细胞学检测单核细胞亚群有助于鉴别诊断,融合基因与单核细胞增加的关系尚不明确。采用酪氨酸激酶抑制剂或者异基因造血干细胞移植治疗。Chronic myeloid leukemia with a significant increase of monocytes is rare and difficult to identify from chronic myelo-monocytic leukemia in clinic.A 31-year-old male patient with systemic pain was initially diagnosed as chronic myelo-monocytic leukemia,who was finally diagnosed as chronic myeloid leukemia by fusion gene and chromosome examination.In addition to the typical Ph chromosome,a rare chromosome translocation t(2;7)(p13;p22)was observed.The detection of monocyte subsets by multi-parameter flow cytometry is a diagnostic marker to distinguish the above 2 diseases.The relationship between fusion genes and mononucleosis is not clear.Tyrosine kinase inhibitors or allogeneic hematopoietic stem cell transplantation can be used in the treatment for this disease.

关 键 词：慢性粒细胞白血病 慢性粒-单核细胞白血病 染色体易位t(2 7)(p13 p22) 

分 类 号：R733.72[医药卫生—肿瘤]