基于系统生物学方法的慢性胃炎病证研究概述  

Review of the research of chronic gastritis and its syndromes based on systems biology approach

作　　者：冯依伊 房雨晨 王忆勤[1] 郝一鸣[1] FENG Yi-yi;FANG Yu-chen;WANG Yi-qin;HAO Yi-ming(Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学,上海市健康辨识与评估重点实验室/中医四诊信息化实验室,上海201203

出　　处：《中华中医药杂志》2021年第3期1548-1552,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年科学基金项目(No.81703982);国家基础科学人才培养基金项目 (No.J1103607)。

摘　　要：系统生物学方法是一个由上而下的系统整合过程,符合中医学理论的整体观念,适用于中医证候的本质研究。因此,随着系统生物学方法的不断发展,运用该技术探讨慢性胃炎病证的物质基础和作用机制越来越受到研究者的关注。近年来,广大研究者们运用基因组学、蛋白质组学、代谢组学和微生物组学等系统生物学方法开展了慢性胃炎中医病证发生机制、病证诊断标志物、微生物与宿主相互作用等研究。文章分别从慢性胃炎的疾病和证候研究两方面,对近20余年的国内外研究现状进行概述,指出了目前研究的不足,并提出了今后运用系统生物学方法开展慢性胃炎病证研究的方向和策略。Systems biology approach is a top-down systematic integration,which accords with holistic concept of TCM theory and suits the research on the essence of TCM syndromes.Therefore,as the approach develops continuously,increased attention has been drawn to its application on the material foundation and mechanism of chronic gastritis and its syndromes.In recent years,researchers applied genomics,proteomics,metabolomics,and microbiome to study the generative mechanism of the syndromes of chronic gastritis,biomarkers of syndrome diagnosis,the interaction between microbe and host,etc.Domestic and foreign studies in recent 20 years were summarized from the perspective of disease and syndrome respectively.The shortcomings of the present studies were pointed out,and the direction and strategies of relevant researches were suggested henceforth.

关 键 词：慢性胃炎 证候 系统生物学 组学 综述 

分 类 号：R259[医药卫生—中西医结合]