代谢相关脂肪性肝病慢加急性肝衰竭的过去、现状与未来  

Acute-on-chronic liver failure in patients with metabolic associated fatty liver disease:Past,Present,and Future

作　　者：缪磊 唐梁杰 范建高[3,4] 郑明华 MIAO Lei;TANG Liangjie;FAN Jiangao;ZHENG Minghua(NAFLD Research Center/Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;Department of Gastroenterology,Yuying Children’s Hospital,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;Department of Gastroenterology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,Shanghai 200092,China;Institute of Hepatology,Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州医科大学附属第一医院感染内科/脂肪肝中心,浙江温州325000 [2]温州医科大学附属第二医院,育英儿童医院消化内科,浙江温州325000 [3]上海交通大学医学院附属新华医院消化内科,上海200092 [4]上海市小儿消化与营养重点实验室,上海200092 [5]温州医科大学肝病研究所,浙江温州325000 [6]浙江省慢性肝病重症化精准诊治与转化重点实验室,浙江温州325000

出　　处：《临床肝胆病杂志》2021年第4期761-764,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(81500665,82070588);浙江省卫生厅高层次创新人才项目(S2032102600032);温州市新世纪551人才项目。

摘　　要：代谢相关脂肪性肝病(MAFLD)是目前脂肪性肝病领域的热议话题,它已成为全球最常见的慢性肝病。预计在未来的20年内,MAFLD及相关肝硬化的发病率仍将不断增加,成为新的全球性健康问题。慢加急性肝衰竭(ACLF)是指在慢性肝病基础上,短期内发生的急性或亚急性肝功能失代偿状态,以腹水、黄疸、凝血功能障碍和肝性脑病为主要表现的临床症候群。在有限的资料基础上,对MAFLD-ACLF的流行病学、发病机制和治疗管理策略等问题进行讨论和展望。Metabolic associated fatty liver disease(MAFLD)is a hotspot in the field of fatty liver disease at present and it has become the most common chronic liver disease around the world.It is predicted that the incidence rates of MAFLD and related liver cirrhosis will continue to grow in the next 20 years and that they will become new global health issues.Acute-on-chronic liver failure(ACLF)is defined as a clinical syndrome of acute or subacute liver function decompensation within a short period of time in the presence of existing chronic liver diseases,with the main clinical manifestations of ascites,jaundice,coagulation disorder,and hepatic encephalopathy.Based on the existing data,this article discusses the epidemiology,pathogenesis,treatment and management strategies,and future prospects of MAFLD-ACLF.

关 键 词：代谢相关脂肪性肝病 慢加急性肝功能衰竭 肝移植 

分 类 号：R575.5[医药卫生—消化系统]