饮食对非酒精性脂肪性肝病肠道微生物菌型相关菌群的影响  

Effect of diet on enterotype-related gut microbiota in nonalcoholic fatty liver disease

作　　者：刘巧红 赵瑜 胡义扬[1,2,3] LIU Qiaohong;ZHAO Yu;HU Yiyang(Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203 [2]上海市中医临床重点实验室,上海201203 [3]肝肾疾病病证教育部重点实验室,上海201203

出　　处：《临床肝胆病杂志》2021年第4期939-942,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金重点项目(81830119);上海市申康行动三年计划项目(16CR1019A)。

摘　　要：非酒精性脂肪性肝病(NAFLD)是一种典型的慢性肝病,与肠道微生态的失调密切相关。饮食因素可能是影响肠道细菌组成和功能的最重要的驱动因素。基于肠道微生物菌型的概念,总结了饮食对NAFLD肠道微生物菌型相关菌群的影响,包含厚壁菌门/拟杆菌门的比值、拟杆菌属、普雷沃菌属、瘤胃球菌属、变形菌门、放线菌门及其他菌。指出改善饮食进而调节肠道菌群是防治NAFLD的重要策略之一,具有良好的前景,但尚需进一步的机制和临床研究。Nonalcoholic fatty liver disease(NAFLD)is a typical chronic liver disease closely associated with gut dysbiosis,and dietary factor may be the most important driving factor affecting the composition and function of intestinal bacteria.Based on the concept of enterotype,this article summarizes the effect of diet on enterotype-related gut microbiota in NAFLD,including Firmicutes/Bacteroidetes ratio,Bacteroides,Prevotella,Ruminococcus,Proteobacteria,Actinobacteria,and other bacteria.It is pointed out that improving diet to regulate gut microbiota is one of the important strategies for the prevention and treatment of NAFLD and has a good prospect,which needs further mechanism and clinical research.

关 键 词：非酒精性脂肪性肝病 饮食 肠道微生物菌型 肠道菌群 

分 类 号：R575.5[医药卫生—消化系统]