代谢相关脂肪性肝病的内科治疗进展  

Research advances in medical treatment of metabolic associated fatty liver disease

作　　者：刘素彤 苏凯奇 赵晨露 张丽慧 赵文霞[1,2] LIU Sutong;SU Kaiqi;ZHAO Chenlu;ZHANG Lihui;ZHAO Wenxia(The First Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450046 [2]河南中医药大学第一附属医院脾胃肝胆科,郑州450000

出　　处：《临床肝胆病杂志》2021年第4期947-950,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(81473651);河南省中医药科学研究专项课题(2018JDZX005,2019JDZX2051);河南省科技攻关计划项目(202102310495)。

摘　　要：代谢相关脂肪性肝病(MAFLD)是目前全球范围内最重要的肝病之一,其发病率呈逐年上升的趋势。总结了目前内科治疗MALFD的研究现状,其治疗方式包括生活方式的改变和个体化药物的治疗。其中生活方式的改变有饮食管理、运动干预、生物钟调整和心理干预,个体化药物治疗有胰岛素增敏剂、维生素E、减肥降脂药、保肝降酶药及中医药治疗等。同时,多学科协作的治疗方式是临床治疗MAFLD的大势所趋。Metabolic associated fatty liver disease(MAFLD)is currently one of the most important liver diseases worldwide,and its incidence rate is increasing year by year.This article summarizes the current research status of medical treatment of MAFLD,including lifestyle changes and individualized drug treatment.Lifestyle changes include diet management,exercise intervention,biological clock adjustment,and psychological intervention,and individualized drug treatment includes insulin sensitizer,vitamin E,weight-loss and lipid-lowering drugs,liver-protecting and transaminase-lowering drugs,and traditional Chinese medicine treatment.At the same time,multidisciplinary treatment is the trend of clinical treatment of MAFLD.

关 键 词：代谢相关脂肪性肝病 生活方式 药物疗法 

分 类 号：R575.5[医药卫生—消化系统]