Kupffer细胞在原发性胆汁性胆管炎发生发展中的作用  

Role of Kupffer cells in the development and progression of primary biliary cholangitis

作　　者：付海艳 唐映梅[1] FU Haiyan;TANG Yingmei(Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China)

机构地区：[1]昆明医科大学第二附属医院消化内科,昆明650000

出　　处：《临床肝胆病杂志》2021年第4期959-961,共3页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81360072,8176030241,8166030160)。

摘　　要：原发性胆汁性胆管炎(PBC)发病率逐年增加,但目前尚无特效药物,发病机制复杂。Kupffer细胞作为调节免疫的关键细胞,在PBC中的作用不容忽视。肝细胞受损时,Kupffer细胞被激活,释放大量炎症因子和趋化因子,参与PBC的发生发展。从Kupffer细胞在PBC中的作用进行简要阐述和分析,为Kupffer细胞作为PBC治疗的可能靶点提供部分理论依据。The incidence rate of primary biliary cholangitis(PBC)is increasing year by year,but there is still no specific medicine at present and PBC has a complex pathogenesis.Kupffer cells,as the key cells involved in immunoregulation,play an important role in PBC.When hepatocytes are damaged,Kupffer cells will be activated and release a large amount of inflammatory cytokines and chemokines,which participate in the development and progression of PBC.This article briefly reviews the role of Kupffer cells in PBC,so as to provide a theoretical basis for Kupffer cells as a potential target for the treatment of PBC.

关 键 词：肝硬化 胆汁性 KUPFFER细胞 炎症 氧化应激 

分 类 号：R575.22[医药卫生—消化系统]