石龙解毒方治疗弥漫大B细胞淋巴瘤临床研究  

Effect of Shilong Jiedu recipe on serum beta 2-MG and LDH in patients with diffuse large B-cell lymphoma

作　　者：肖汇颖[1] 胡冬菊[1] 贾海波[2] 王永敏[1] 籍祥瑞 杨凯 XIAO Huiying;HU Dongju;JIA Haibo;WANG Yongmin;JI Xiangrui;YANG Kai(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China)

机构地区：[1]河北省中医院,河北石家庄050011 [2]河北省人民医院中医科,河北石家庄050011

出　　处：《陕西中医》2021年第4期478-481,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2017034)。

摘　　要：目的:观察石龙解毒方对弥漫大B细胞淋巴瘤患者血清β2-微球蛋白(β2-MG)与乳酸脱氢酶(LDH)的影响。方法:将弥漫大B细胞淋巴瘤80例患者按照随机对照法分为观察组和对照组,每组40例。对照组采用CHOP方案治疗,观察组在采用CHOP方案治疗的同时,口服石龙解毒汤辅助治疗。3周为1个疗程,连用6个疗程。观察两组治疗疗效,比较治疗前后中医证候积分、中医治疗疗效,治疗前后免疫细胞因子水平,β2-MG与LDH水平,两组不良反应发生情况。结果:观察组总有效率和对照组相比,差异无统计学意义(P>0.05);观察组治疗后中医证候积分低于对照组(P<0.05);观察组治疗后中医证候疗效高于对照组(P<0.05);观察组治疗后血清β2-MG与LDH水平均低于对照组(P<0.05);观察组治疗后CD 3^(+)、CD 4^(+)、CD 19^(+)细胞比例均明显高于对照组,CD 8^(+)细胞比例和对照组比较差异无统计学意义(P>0.05);观察组不良反应总发生率低于对照组(P<0.05)。结论:石龙解毒方治疗弥漫大B细胞淋巴瘤疗效确切,能降低血清β2-MG与LDH水平,提高化疗患者的免疫力,减毒增效。Objective:To observe the effect of Shilong Jiedu recipe on serum beta 2-MG and Lactate dehydroglobulin(LDH)in patients with diffuse large B-cell lymphoma.Methods:A total of 80 patients with diffuse large B-cell lymphoma were selected as the study subjects.According to the randomized control method,the patients were divided into observation group and control group,with 40 patients in each group.The patients in the control group were treated with CHOP regimen,while the patients in the observation group were treated with CHOP regimen,and the patients in the observation group were treated with Shilong Jiedu recipe.Three weeks course of treatment,six courses of treatment.Compared the curative effect of the two groups,the scores of TCM symptoms before and after treatment,the curative effect of TCM treatment,the levels of immune cytokines,beta 2-MG and LDH before and after treatment,and compare the occurrence of adverse reactions between the two groups.Results:There was no significant difference between the observation group and the control group(P>0.05).Observation group after treatment of TCM symptom score lower than the control group(P<0.05).Observation group after treatment of TCM symptoms curative effect was higher than the control group(P<0.05).Observation group after treatment serum beta 2-MG and LDH level was lower than the control group(P<0.05).After treatment,the proportion of CD 3^(+),CD 4^(+)and CD 19^(+)cells in the observation group was significantly higher than that in the control group,while the proportion of CD 8^(+)cells in the observation group was not significantly different from that in the control group(P>0.05).Incidence of adverse reactions to the total observation group was lower than the control group(P<0.05).Conclusion:Shilong Jiedu recipe for diffuse large B cell lymphoma has a definite effect,can reduce the serumβ2-MG and LDH levels,improve the immunity of chemotherapy patients,reduce toxicity and increase efficacy.

关 键 词：石龙解毒方 弥漫大B细胞淋巴瘤 血清Β2-微球蛋白 乳酸脱氢酶 免疫功能 化疗 

分 类 号：R733.4[医药卫生—肿瘤]