侵袭性牙周炎患者疱疹病毒感染和外周血病毒载量  

Herpes virus infection and viral loads in peripheral blood of patients with aggressive periodontitis

作　　者：赵青侠 满夫霞 刘金盼[1] 王倩 宋岩 ZHAO Qing-xia;MAN Fu-xia;LIU Jin-pan;WANG Qian;SONG Yan(Shizhong District People's Hospital,Jinan,Shandong250001,China)

机构地区：[1]济南市市中区人民医院口腔科,山东济南250001 [2]枣庄市山亭区人民医院口腔科,山东枣庄277200

出　　处：《中华医院感染学杂志》2021年第5期744-748,共5页Chinese Journal of Nosocomiology

基　　金：山东省科研基金资助项目(201912104)。

摘　　要：目的分析不同严重程度侵袭性牙周炎(AGP)患者疱疹病毒(HV)感染情况和外周血病毒载量。方法选取2014年12月-2019年12月济南市市中区人民医院口腔科收治的2600例AGP患者,根据病变程度分为轻度AGP组(n=82)、中度AGP组(n=578)、重度AGP组(n=1940),以同期100名健康人群为对照组。入组后,检测龈沟液HV病毒感染情况和血浆单纯疱疹病毒1型(HSV-1)、EB病毒(EBV)、人类巨细胞病毒(HCMV)、人类疱疹病毒6型(HHV-6)载量、牙周特征和血炎症因子水平。结果AGP患者牙周菌斑指数(PLI)、探诊深度(PD)、附着丧失(AL)、出血指数(BI)高于对照组(P<0.05),HSV-1、EBV、HCMV、HHV-6感染率和病毒载量高于对照组(P<0.05),白细胞(WBC)、降钙素原(PCT)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)高于对照组(P<0.05);随着AGP病情严重程度增加,HSV-1、EBV、HCMV、HHV-6感染率和病毒载量、PLI、PD、AL、BI、WBC、PCT、IL-6、TNF-α和CRP均增加(P<0.05)。结论HV感染率和病毒载量与AGP患者血清炎症因子水平和牙周特征随病情严重程度增加而升高。OBJECTIVE To explore the prevalence of herpes virus(HV)infection and viral loads in peripheral blood of the patients with different severities of aggressive periodontitis(AGP).METHODS A total of 2600 AGP patients who were treated in stomatology department of Shizhong District People’s Hospital from Dec 2014 to Dec 2019 were enrolled in the study and divided into the mild AGP group with 82 cases,the moderate AGP group with 578 cases and the severe AGP group with 1940 cases according to the severity of lesions,meanwhile,100 healthy people were set as the control group.The prevalence of HV infection in gingival crevicular fluid,loads of plasma herpes simplex virus-1(HSV-1),Epstein-Barr virus(EBV),human cytomegalovirus(HCMV)and human herpes virus-6(HHV-6),periodontal features and serum inflammatory factors were detected.RESULTS The plaque index(PLI),probing depth(PD),attachment loss(AL)and bleeding index(BI)of the AGP patients were higher than those of the subjects in the control group(P<0.05).The incidence rates of HSV-1,EBV,HCMV and HHV-6 infections as well as the viral loads were significantly higher among the patients with AGP than among the subjects in the control group(P<0.05).The levels of white blood cell(WBC),procalcitonin(PCT),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)of the patients with AGP were significantly higher than those of the subjects in the control group(P<0.05).With the aggravation of AGP,the incidence rates of HSV-1,EBV,HCMV and HHV-6 infections,viral loads,PLI,PD,AL,BI,WBC,PCT,IL-6,TNF-αand CRP were significantly increased(P<0.05).CONCLUSION The incidence of HV infection,viral loads,levels of serum inflammatory factors and periodontal features of the AGP patients are increased with the severity of illness condition.

关 键 词：侵袭性牙周炎 疱疹病毒 炎症因子 牙周特征 

分 类 号：R781.4[医药卫生—口腔医学]