CTCs与结直肠癌病理特征及术后复发的关系研究  

Relationship Between CTCs and Clinicopathological Features and Postoperative Recurrence of Colorectal Cancer

作　　者：吕焱 LYU Yan(School of Basic Medicine,Binzhou Medical University,YantaiShandong 264010,China;Laboratory Department,Liaocheng People’sHospital,Liaocheng Shandong 252000,China)

机构地区：[1]滨州医学院基础医学院,山东烟台264010 [2]聊城市人民医院检验科,山东聊城252000

出　　处：《中国卫生标准管理》2021年第6期53-58,共6页China Health Standard Management

摘　　要：目的通过检测结直肠癌患者术前外周血循环肿瘤细胞(CTCs),探讨结直肠癌患者术前CTCs检出水平与临床病理特征及预后的关系。方法收集2017年3月1日-2019年6月30日的40例结直肠癌患者及36例良性疾病患者的外周血,采用FISH法检测CTCs,比较两组患者的CTCs检出水平、癌胚抗原(carcinoembryonic antigen,CEA)、TNM分期(T是原发灶,N是淋巴结,M是远处转移)、肿瘤分化程度、脉管癌栓之间的关系,并进行统计学分析。结果 (1)结直肠癌组中CTCs阳性率为62.5%,良性肿瘤对照组中阳性率为5.6%,差异具有统计学意义(P <0.05)。(2)结直肠癌患者组术前CTCs阳性率高于CEA(P <0.05)。(3)CTCs术前阴性组患者术后复发的风险低于CTCs阳性组(P <0.05)。(4)术前CTCs阳性患者的术后病理结果中,脉管癌栓阳性率高于CTCs阴性组(P <0.05)。结论 CTCs在恶性肿瘤中表达比良性肿瘤高,对恶性肿瘤的诊断有较大的指导意义。CTCs敏感性高于CEA,两者结合可提高结直肠癌的检出率。CTCs阳性的结直肠癌患者出现脉管癌栓率较高,复发危险度较高,可作为结直肠癌预后的重要指标。Objective To investigate the relationship between the detection level of circulating tumor cells(CTCs)and clinicopathological features and prognosis in patients with colorectal cancer.Methods The peripheral blood of 40 patients with colorectal cancer and 36 patients with benign diseases were collected from March 1st,2017 to June 30th,2019.CTCs were detected by fish.The detection level of CTCS and carcinoembryonic antigen(CEA)were compared between the two groups The relationship between tumor differentiation,TNM stage(T is primary tumor,N is lymph node,M is distant metastasis),tumor differentiation and vascular tumor thrombus was analyzed statistically.Results(1)The positive rate of CTCS was 62.5%in colorectal cancer group and 5.6%in benign tumor control group(P<0.05).(2)The positive rate of CTCS in colorectal cancer group was higher than that in CEA group(P<0.05).(3)The risk of postoperative recurrence in CTCs negative group was lower than that in CTCs positive group(P<0.05).(4)The positive rate of vascular cancer thrombus in patients with positive CTCs before operation was higher than that in patients with negative CTCs(P<0.05).Conclusion The expression of CTCS in malignant tumors is higher than that in benign tumors,which has great guiding significance for the diagnosis of malignant tumors.The sensitivity of CTCS is higher than that of CEA.The combination of CTCS and CEA can improve the detection rate of colorectal cancer.CTCs positive colorectal cancer patients have higher incidence of vascular tumor thrombus and higher risk of recurrence,which can be used as an important indicator of prognosis of colorectal cancer.

关 键 词：结直肠癌 CTCS 肿瘤部位 无瘤生存期 脉管癌栓 预后 

分 类 号：R735[医药卫生—肿瘤]