胸腔积液与血清癌胚抗原比值对胸腔积液性质的诊断效果  

Diagnostic efficacy of the ratio of carcinoembryonic antigen in pleural effusion and serum for the nature of pleural effusion

作　　者：张业标 周正平[1] 沈冬明[1] 严春霞[1] ZHANG Ye-biao;ZHOU Zheng-ping;SHEN Dong-ming;YAN Chun-xia(Department of Clinical Laboratory,Luodian Hospital of Shanghai Baoshan District,Shanghai 201908,China)

机构地区：[1]上海市宝山区罗店医院检验科,上海201908

出　　处：《中国肿瘤临床与康复》2021年第2期210-213,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨胸腔积液与血清癌胚抗原比值对胸腔积液性质的诊断效果。方法选取2018年1月至2019年10月间上海市宝山区罗店医院收治的86例胸腔积液患者,按照胸腔积液良恶性质将患者分为恶性组34例和良性组52例。使用电化学发光免疫分析法检测患者的胸腔积液、血清癌胚抗原水平,计算两者比值,比较两组患者及恶性组不同病理类型的上述指标水平的高低以及阳性率差异。结果恶性组患者胸腔积液癌胚抗原水平为(28.26±5.92)ng/ml,血清癌胚抗原水平为(14.29±3.61)ng/ml,比值为(2.16±0.74),良性组患者胸腔积液癌胚抗原水平为(1.03±0.44)ng/ml,血清癌胚抗原水平为(2.21±0.67)ng/ml,比值为(0.53±0.21),恶性组上述指标均高于良性组,差异均有统计学意义(均P<0.05)。恶性组患者胸腔积液癌胚抗原阳性率为91.2%,血清癌胚抗原阳性率为85.3%,胸腔积液与血清癌胚抗原比值阳性率为91.2%,良性组的胸腔积液癌胚抗原阳性率为7.7%,血清癌胚抗原阳性率为11.5%,胸腔积液与血清癌胚抗原比值阳性率为1.9%,恶性组上述指标均高于良性组,差异均有统计学意义(均P<0.05)。结论联合检测胸腔积液和血清癌胚抗原水平及两者比值,有助于鉴别胸腔积液良恶性,且敏感性高,具有重要的临床价值。Objective To explore the diagnostic efficacy of the ratio of carcinoembryonic antigen in pleural effusion and serum for the nature of pleural effusion.Methods Eighty-six patients with pleural effusion admitted to Luodian Hospital of Shanghai Baoshan District from January 2018 to October 2019 were selected as the research subjects.They were divided into a benign group(52 patients)and a malignant group(34 patients).Electrochemiluminescence immunoassay was used to detect their levels and the ratio of carcinoembryonic antigen in pleural effusion and serum was calculated.The level of the above indicators and the difference in the positivity rate were compared between the two groups of patients of different pathological types.Results The level of carcinoembryonic antigen was 28.26±5.92 ng/ml in pleural effusion and 14.29±3.61 ng/ml in serum in the malignant group with a ratio of 2.16±0.74.In the benign group,the level of carcinoembryonic antigen was 1.03±0.44 ng/ml and 2.21±0.67 ng/ml,respectively with a ratio of 0.53±0.21(all P<0.05).In the malignant group,the positivity rate of carcinoembryonic antigen was 91.2%in pleural effusion and 85.3%in the serum,and the positivity rate of their ratio was 91.2%.In the benign group,the positivity rate of carcinoembryonic antigen was 7.7%and 11.5%,respectively and the positivity rate of their ratio was 1.9%(all P<0.05).The above indices were higher in the malignant group than in the benign group(all P<0.05).Conclusion The joint detection of pleu-ral effusion and serum carcinoembryonic antigen level and their ratio can help to distinguish benign and malignant pleural effusion and malignant pathological types with high sensitivity and important clinical value.

关 键 词：胸腔积液 血清 癌胚抗原 诊断效果 

分 类 号：R730.4[医药卫生—肿瘤]