Clinical laboratory features of Meigs’syndrome:a retrospective study from 2009 to 2018  

作　　者：Wenwen Shang Lei Wu Rui Xu Xian Chen Shasha Yao Peijun Huang Fang Wang 

机构地区：[1]Department of Laboratory Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China [2]National Key Clinical Department of Laboratory Medicine,Nanjing 210029,China

出　　处：《Frontiers of Medicine》2021年第1期116-124,共9页医学前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81772779);“Professionals from SixPronged Top-Talent Program”of Jiangsu Province(No.LGY2017068);“The Six Top Talent Project”of Jiangsu Province(No.2015-WSN-034);Medical Talent of Empowering Medicine through Science and Education Program of Jiangsu Province(No.ZDRCA2016003);Key Laboratory for Medicine of Jiangsu Province of China(No.ZDXKB2016005).

摘　　要：Meigs’syndrome(MS),a rare complication of benign ovarian tumors,is easily misdiagnosed as ovarian cancer(OC).We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018.Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma(OTF)and healthy control groups(all P<0.05).However,the serum HE4 levels were lower in the MS group than in the OC group(P<0.001).A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups(all P<0.05).However,these variables were higher in the MS group than in the OC group(both P<0.05).The neutrophil-to-lymphocyte ratio(NLR)was also significantly lower,whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group(both P<0.05).The NLR,platelet-to-lymphocyte ratio,and systemic immune index were significantly higher in the MS group than in the OTF and control groups(all P<0.05).The hypoxia-inducible factor-1 mRNA levels were also significantly higher,whereas the glucose transporter 1,lactate dehydrogenase,and enolase 1 mRNA levels were lower in peripheral CD4+T cells obtained preoperatively in a patient with MS than those in patients with OTF,patients with OC,and controls(all P<0.05).The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS(P<0.001).These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS.

关 键 词：Meigs’syndrome ovarian thecoma-fibroma NLR(neutrophil to lymphocyte ratio) CD4^(+)T cells glucose metabolism 

分 类 号：R737.31[医药卫生—肿瘤]