Altered white matter microarchitecture in Parkinson’s disease:a voxel-based meta-analysis of diffusion tensor imaging studies  

作　　者：Xueling Suo Du Lei Wenbin Li Lei Li Jing Dai Song Wang Nannan Li Lan Cheng Rong Peng Graham J Kemp Qiyong Gong 

机构地区：[1]Huaxi MR Research Center(HMRRC),Department of Radiology,West China Hospital of Sichuan University,Chengdu 610041,China [2]Department of Psychiatry and Behavioral Neuroscience,University of Cincinnati,Cincinnati,Ohio,USA [3]Department of Psychoradiology,Chengdu Mental Health Center,Chengdu 610041,China [4]Department of Neurology,West China Hospital of Sichuan University,Chengdu 610041,China [5]Liverpool Magnetic Resonance Imaging Centre(LiMRIC)and Institute of Ageing and Chronic Disease,University of Liverpool,Liverpool L693GE,United Kingdom [6]Psychoradiology Research Unit of Chinese Academy of Medical Sciences,West China Hospital of Sichuan University,Chengdu 610041,China

出　　处：《Frontiers of Medicine》2021年第1期125-138,共14页医学前沿（英文版）

基　　金：supported by the National Natural Science Foundation(Nos.81621003,81761128023,81220108013,81227002,and 81030027);the Program for Innovative Research Team in University(No.IRT16R52)of China;the Professorship Award(No.T2014190)of China;the CMB Distinguished Professorship Award(No.F510000/G16916411)administered by the Institute of International Education.

摘　　要：This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses.

关 键 词：Parkinson’s disease diffusion tensor imaging fractional anisotropy META-ANALYSIS anisotropic effect size-signed differential mapping 

分 类 号：R742.5[医药卫生—神经病学与精神病学]