p38MAPK信号转导通路与肿瘤关系的最新研究进展  

Recent research progress on the relationship between p38MAPK signal transduction pathway and tumor

作　　者：鲜文佳 李祖茂[1] XIAN Wenjia;LI Zumao(Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院,四川南充637000

出　　处：《临床医学研究与实践》2021年第10期193-195,共3页Clinical Research and Practice

摘　　要：丝裂原活化蛋白激酶(MAPK)级联是细胞内广泛存在的一类丝/苏氨酸蛋白激酶超家族,其亚族主要包括细胞外信号调节激酶(ERK)、c-Jun氨基末端激酶/应激激活蛋白激酶(JNK/SAPK)和p38MAPK。他们主要是将细胞外信号转入细胞核内并引起相应变化的重要信号通路,调节细胞生长、分化、对环境的应激适应、炎症反应等多种细胞生理/病理过程。迄今为止各类研究发现,p38MAPK可介导应激、炎性因子及生长因子等多种刺激引起的细胞反应,也可以通过下游效应蛋白磷酸化而改变基因的表达水平,获得不同的细胞效应应答,参与各种肿瘤细胞的发生、侵袭、转移和耐药等过程,故阐明p38MAPK信号通路参与不同肿瘤的调控机制,将为不同肿瘤的诊治过程提供新的门径。Mitogen-activated protein kinase(MAPK)cascade is an extensive intracellular silk/threonine protein kinase superfamily,whose subgroups mainly include extracellular signal-regulated protein kinases(ERK),c-Jun N-terminal kinase/stress-activated protein kinase(JNK/SAPK)and p38MAPK.They are mainly important signaling pathways that transfer extracellular signals into the nucleus and cause corresponding changes,regulating various cellular physiological/pathological processes such as cell growth,differentiation,stress adaptation to the environment,and inflammatory response.So far all kinds of research found that p38MAPK can mediate cellular responses induced by stress,inflammatory cytokines and growth factors and other stimulus,and can also change gene expression level through the phosphorylation of downstream effector proteins,obtain the different cellular response,to participate in the occurrence,invasion,metastasis and drug resistance of various tumor cells,so to clarify p38MAPK signaling pathways involved in different regulatory mechanism of tumor,will provide a new path for the diagnosis and treatment process of different tumors.

关 键 词：P38丝裂原活化蛋白激酶 肿瘤 信号通路 

分 类 号：R73[医药卫生—肿瘤]