抗精神病药物与乳腺癌发生风险的关系研究及对PRL水平的影响  

Relationship between antipsychotics and risk of breast cancer

作　　者：何岩 李红伟[1] 范柳笛[1] HE Yan;LI Hong-wei;FAN Liu-di(The First Department of General Surgery,Central Hospital of Luohe,Luohe,Henan 462000,China)

机构地区：[1]漯河市中心医院普外一科,河南漯河462000

出　　处：《医药论坛杂志》2021年第4期43-46,共4页Journal of Medical Forum

基　　金：2018年河南省科技攻关计划项目(201802351)。

摘　　要：目的探讨口服抗精神病药物的患者发生乳腺癌的风险。方法回顾性分析1990年1月至2019年12月漯河市中心医院就诊的乳腺肿瘤合并精神疾病的患者312例临床资料,患者均行手术治疗并有明确的病理结果,根据病理结果,良性肿瘤190例,乳腺癌122例,其中口服抗精神病药物患者为观察组,共194例,未服药物患者为对照组,共118例;应用SPSS 22.0系统,探讨口服抗精神病药物与未服药物的患者发生乳腺癌的风险,并观察催乳素水平的变化情况。结果观察组中乳腺癌98例,良性肿瘤96例,对照组中乳腺癌24例,良性肿瘤94例,差异具有统计学意义(χ^(2)值为28.058,P<0.05);口服抗精神病药物患者术前催乳素水平均数为(46.41±12.31)ng/mL,未服药物患者的催乳素水平均数为(10.98±4.91)ng/mL,对比差异具有统计学意义(χ^(2)值为188.21,P<0.05);两组患者患乳腺癌的OR值为3.998。结论口服抗精神病药物患者催乳素水平明显升高,患乳腺癌风险是未服药物患者的3.998倍。抗精神病药物诱导的催乳素水平升高会增加精神疾病患者患乳腺癌的风险。Objective To investigate the risk of breast cancer in patients with mental illness and oral antipsychotics.Methods A retrospective analysis was made of the clinical data of 312 patients with breast tumor complicated with mental diseases who were admitted to Luo he central hospital from January 1990 to December 2019. All the patients received surgical treatment and had clear pathological results. According to the pathological results, 190 patients had benign tumors and 122 patients had breast cancer. The observation group consisted of 194 patients with oral antipsychotics, and the control group consisted of 118 patients without oral antipsychotics. Using the SPSS 22.0 system and χ^(2) test, the risk of breast cancer in patients with oral antipsychotic drugs and those without drugs was investigated.Results There were 98 cases of breast cancer in the observation group, including 96 cases of benign tumor, 24 cases of breast cancer in the control group, and 94 cases of benign tumor. The mean preoperative prolactin level of patients with oral antipsychotic drugs was(46.41±12.31)ng/mL, while the mean preoperative prolactin level of patients without drugs was(10.98±4.91)ng/mL, χ^(2) value was 188.21, P<0.05, showing statistical differences. The OR value of breast cancer in the two groups was 3.998.Conclusion Prolactin levels were significantly higher in patients with oral antipsychotics, and the risk of breast cancer was 3.998 times higher in those who did not take the drugs. Increased levels of prolactin induced by antipsychotics increase the risk of breast cancer in people with mental illness.

关 键 词：抗精神病药物 乳腺癌 乳腺良性肿瘤 精神疾病 

分 类 号：R737.9[医药卫生—肿瘤]