抗生素对免疫检查点抑制剂治疗非小细胞肺癌疗效影响的Meta分析  

Effect of antibiotics on treatment efficacy of immune checkpoint inhibitors in non-small cell lung cancer:A Meta-analysis

作　　者：霍庚崴 宋莹 陈卫东[2] 种道群[2] 贾沙沙 陈鹏 HUO Gengwei;SONG Ying;CHEN Weidong;CHONG Daoqun;JIA Shasha;CHEN Peng(Department of Thoracic Oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,Tianjins Clinical Research Center for Cancer,Tianjin Lung Cancer Center,Key Laboratory of Cancer Immunology and Biotherapy,Tianjin,Tianjin 300060,China;Department of Oncology,Jining No.1 People’s Hospital,Jining 272000,Shandong,China;Department of Pharmacy,Jining No.1 People’s Hospital,Jining 272000,Shandong,China)

机构地区：[1]天津医科大学肿瘤医院肺部肿瘤内科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心天津市肺癌诊治中心天津市肿瘤免疫与生物治疗重点实验室,天津300060 [2]济宁市第一人民医院肿瘤科,山东济宁272000 [3]济宁市第一人民医院药学部,山东济宁272000

出　　处：《中国肿瘤生物治疗杂志》2021年第2期165-170,共6页Chinese Journal of Cancer Biotherapy

基　　金：天津市科学技术委员会重大项目(No.18ZXDBSY00050)。

摘　　要：目的:通过Meta分析的方法评价抗生素对免疫检查点抑制剂治疗非小细胞肺癌(non-small lung cancer,NSCLC)疗效的影响。方法:检索Pubmed、Cochrane Library、EMbase、EBSCO循证医学数据库、中国生物医学文献数据库(CBM)、中国知网(CNKI)中收录的关于抗生素对免疫检查点抑制剂治疗NSCLC疗效影响的相关文献,采用RevMan 5.3软件对疗效进行Meta分析。结果:纳入14篇文献共2505例NSCLC患者,Meta分析结果显示,抗生素的应用可显著缩短免疫检查点抑制剂治疗NSCLC患者的PFS(HR=1.14,95%CI=1.04-1.26,P=0.005)和OS(HR=1.30,95%CI=1.14-1.47,P<0.0001)。结论:免疫检查点抑制剂治疗NSCLC之前、同步或之后应用抗生素可能显著缩短PFS和OS,对疗效有可能产生不利影响。Objective:To investigate the effects of antibiotics on the treatment efficacy of immune checkpoint inhibitors in NSCLC(non-small cell lung cancer)with Meta-analysis.Methods:Literatures regarding the effects of antibiotics on the treatment efficacy of immune checkpoint inhibitors in NSCLC were searched in Pubmed,Cochrane Library,Embase,EBSCO,Chinese Biomedical Literature Database(CBM)and Chinese Journal Full-text Database(CNKI).RevMan 5.3 software was used in this Meta-analysis.Results:Fourteen articles involving 2505 NSCLC patients were included in this study.Meta-analysis showed that the application of antibiotics could significantly shorten the PFS(HR=1.14,95%CI=1.04-1.26,P=0.005)and OS(HR=1.30,95%CI=1.14-1.47,P<0.0001)of NSCLC patients treated with immune checkpoint inhibitors.Conclusion:Application of antibiotics before,concurrently or after immune checkpoint inhibitors in the treatment of NSCLC may significantly shorten PFS and OS,resulting in adverse effect on treatment efficacy.

关 键 词：非小细胞肺癌 免疫检查点抑制剂 抗生素 程序性死亡受体1 程序性死亡配体1 

分 类 号：R734.1[医药卫生—肿瘤]