天然芪类化合物及其抗α-葡萄糖苷酶活性的研究进展  

Research progress on natural stilbenes and its inhibitory activity on α-glucosidase

作　　者：姜丽丽[1] 尹航[1] 闫明睿 范晓宇 贾艳艳[1] 刘勇[1] JIANG Lili;YIN Hang;YAN Mingrui;FAN Xiaoyu;JIA Yanyan;LIU Yong(School of Life and Pharmaceutical Sciences,Dalian University of Technology,Panjin 124221,Liaoning,China)

机构地区：[1]大连理工大学生命科学与药学学院,辽宁盘锦124221

出　　处：《上海中医药大学学报》2021年第2期116-124,共9页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2017YFC1702006)。

摘　　要：天然芪类化合物是一类以二苯乙烯为骨架结构的天然植物多酚类化合物,是潜在的天然药物来源。因其具有抗肿瘤、抗氧化、抗炎、降糖等广泛的生物活性,近几年受到越来越多的关注。α-葡萄糖苷酶抑制剂可延缓肠道碳水化合物的吸收,有效降低餐后血糖水平,是治疗2型糖尿病的一类主力药物。然而,现有的α-葡萄糖苷酶抑制剂常会引起腹泻、腹部绞痛、肠胃胀气、呕吐等不良反应,故从天然产物中寻找和开发新的α-葡萄糖苷酶抑制剂具有重要意义。从天然芪类化合物的来源分布、抗糖尿病活性及抗α-葡萄糖苷酶活性等方面进行综述,为寻找新的、安全有效的α-葡萄糖苷酶抑制剂类降糖药物提供依据。Natural stilbenes, structurally characterized by the presence of 1, 2-diphenylethylene, are a class of plant polyphenols, as well as potential source of natural medicines. Due to their wide biological activities, including antitumor, antioxidation, anti-inflammation and anti-diabetes, the stilbenes have attracted more and more attention in recent years. Inhibitor of α-glucosidase can delay the absorption of intestinal carbohydrates and effectively decrease the level of postprandial blood glucose, which is the major drug for the treatment of type 2 diabetes. However, the existing α-glucosidase inhibitors often cause the adverse reactions such as diarrhea, abdominal cramps, flatulence and vomiting. Therefore, it is of great significance to find and develop the new α-glucosidase inhibitors from natural products. This paper summarizes the source distribution, anti-diabetes activity and anti-α-glucosidase activity of natural stilbenes, so as to provide reference for searching the new, safe and effective α-glucosidase inhibitors.

关 键 词：芪类化合物 Α-葡萄糖苷酶 糖尿病 综述 

分 类 号：R285[医药卫生—中药学]