乙酰辅酶A合成酶2在肿瘤发生发展中的研究进展  

Research progress on acyl-CoA synthetase short chain family member 2 in tumor igenesis and development

作　　者：杨赟 陈德玉[1] Yang Yun;Chen Deyu(Clinical Center of Tumor Therapy,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属医院肿瘤治疗中心,镇江212001

出　　处：《新医学》2021年第4期234-238,共5页Journal of New Medicine

基　　金：国家自然科学基金(81572956);江苏省社会发展基金(BE2017696);江苏省医学创新团队项目(CXTDC2016009)。

摘　　要：乙酰辅酶A是肿瘤快速生长过程中不可或缺的合成代谢原料,根据瓦伯格效应,肿瘤细胞无法通过丙酮酸氧化脱羧产生乙酰辅酶A,其乙酰辅酶A主要由乙酰辅酶A合成酶2(ACSS2)催化短链脂肪酸所合成,即乙酸+辅酶A+ATP=乙酰辅酶A+二磷酸+AMP,表明了ACSS2在维持肿瘤细胞生长方面至关重要。近年来,越来越多的证据表明,ACSS2活性和表达异常与肿瘤增殖、侵袭、转移、抗凋亡和耐药性等密切相关,该文围绕ACSS2在肿瘤中的相关作用及机制的研究进展进行了综述。Acetyl coenzyme A(CoA)is an indispensable synthetic and metabolic material in the process of rapid growth of tumors.According to the Warburg effect,tumor cells can not produce acetyl CoA by oxidative decarboxylation of pyruvate.Acetyl CoA is mainly synthesized by acyl-CoA synthetase short chain family member 2(ACSS2),acetic acid+coenzyme A+ATP=acetyl coenzyme A+diphosphate+AMP,indicating that ACSS2 plays an important role in maintaining the growth of tumor cells.In recent years,more and more evidence has demonstrated that abnormal activity and expression of ACSS2 are closely associated with tumor proliferation,invasion,metastasis,anti-apoptosis and drug resistance,etc.In this article,the research progresses on the role and mechanism of ACSS2 in these tumor characteristics were reviewed.

关 键 词：乙酰辅酶A合成酶2 肿瘤侵袭 肿瘤迁移 肿瘤治疗抵抗 

分 类 号：R730.2[医药卫生—肿瘤]