自噬在膀胱癌中的研究进展  

Research progress of autophagy in bladder cancer

作　　者：陈振杰 黄应龙[1] 王伟[1] 刘靖宇[1] 李海皓[1] 丁明霞[1] CHEN Zhenjie;HUANG Yinglong;WANG Wei;LIU Jingyu;LI Haihao;DING Mingxia(Department of Urology,Second Affiliated Hospital of Kunming Medical University,Yunnan Institute of Urology,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,云南省泌尿外科研究所,昆明650101

出　　处：《临床肿瘤学杂志》2021年第3期272-276,共5页Chinese Clinical Oncology

基　　金：云南省高校创新团队建设资助项目(k1322107);云南省应用基础研究-昆医联合专项[NO.2019FE001(-226)];昆明医科大学第二附属医院院内科技计划资助项目(2019yk017);昆明医科大学研究生创新基金资助项目(2020S046)。

摘　　要：自噬是一种广泛存在于真核生物中高度保守的分解代谢和能量生成过程,通过促进细胞内物质或受损细胞器的降解,为细胞提供可再循环利用的单体物质,用以合成新的成分并产生能量。自噬异常与多种疾病,尤其是癌症的发生、发展密切相关。自噬可以在正常情况下预防癌症的发展,而一旦发展为癌症,自噬又通常会促进肿瘤细胞的存活和生长。大量研究表明,自噬还与肿瘤的耐药和放射抵抗等机制有关。因此,越来越多的学者认为靶向自噬有望成为癌症治疗的新策略。近年来,随着对自噬与癌症的广泛研究,开发针对自噬途径的癌症治疗策略已成为肿瘤领域的研究热点。本文拟就自噬在膀胱癌发生、发展及其治疗中的作用作一综述。Autophagy is a highly conserved catabolism and energy generation process that is widely found in eukaryotes.It promotes the degradation of intracellular materials or damaged organelles,and provides cells with recyclable monomer substances for synthesizing new ingredients and generate energy.Abnormal autophagy is closely related to the occurrence and development of many diseases,especially cancer.Autophagy can prevent the development of cancer under normal circumstances,but once it develops into cancer,autophagy can promote the survival and growth of tumor cells.A large number of studies have shown that autophagy is related to the mechanism of chemotherapy resistance and radioresistance of tumors.Therefore,more and more scholars believe that targeted autophagy is expected to become a new strategy for cancer treatment.In recent years,with the extensive research on autophagy and cancer,the development of cancer treatment strategies targeting autophagy pathways has become a research focus in the field of tumors.This article intends to review the role of autophagy in the development and treatment of bladder cancer.

关 键 词：膀胱癌 自噬 化疗耐药 

分 类 号：R737.14[医药卫生—肿瘤]