阳离子碳点在癌症诊断和基因治疗一体化中的研究进展  

Research progress in the use of cationic carbon dots for the integration of cancer diagnosis with gene treatment

作　　者：岳林君 卫迎迎 樊江波 陈琳[2] 李强[3] 杜晶磊 于世平[1,3] 杨永珍[2] YUE Lin-jun;WEI Ying-ying;FAN Jiang-bo;CHEN Lin;LI Qiang;DU Jing-lei;YU Shi-ping;YANG Yong-zhen(Shanxi Medical University,Taiyuan 030001,China;Key Laboratory of Interface Science and Engineering in Advanced Materials,Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,China;Interventional Treatment Department,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,山西太原030001 [2]太原理工大学新材料界面科学与工程教育部重点实验室,山西太原030024 [3]山西医科大学第二医院介入治疗科,山西太原030001

出　　处：《新型炭材料》2021年第2期373-389,共17页New Carbon Materials

基　　金：山西省优秀人才科技创新项目(201805D211001);国家自然科学基金项目(51803148);中央引导地方科技发展资金(YDZX20201400001722);山西省应用基础研究计划项目(201901D211501,201901D211502).

摘　　要：阳离子碳点(CCDs)是表面带正电荷的一类碳点(CDs),可通过CDs和含氨基(—NH2)的阳离子化合物经“一步法”或“两步法”制备得到,既保留了CDs良好的荧光性能、低毒性及生物相容性,又提高了基因的负载输送能力及细胞摄取能力,使得CCDs在癌症靶向荧光成像和基因治疗领域中有重要的应用价值。本文综述了CCDs的制备方法和优异性能,说明CCDs可作为显像剂及基因的良好靶向载体;此外,还介绍了CCDs用于癌症诊治的基本原理及在癌症诊断和基因治疗方面的应用,并提出目前CCDs面临的问题及未来的发展趋势。As a type of carbon dot(CD)with a positive charge on their surface,cationic carbon dots(CCDs)can be obtained from CDs and amino-containing cationic compounds by one-step or two-step preparation.They not only retain the good fluorescence performance,low toxicity and biocompatibility of CDs,but also improve their gene delivery efficiency and cell uptake capacity.These excellent properties give CCDs potential advantages in the fields of the targeted fluorescence imaging of cancers and gene therapy.This paper reviews the preparation methods and properties of CCDs,suggesting that they can be used as good targeting carriers for imaging cancer and gene therapy.In addition,the basic principles of CCDs for cancer detection and treatment,and their uses in integrated cancer diagnosis and gene therapy are introduced.Current problems and future development trends of CCDs for this purpose are discussed.

关 键 词：阳离子碳点 基因治疗 荧光成像 癌症诊治一体化 

分 类 号：R730[医药卫生—肿瘤]