碘营养状况和尿碘浓度与甲状腺乳头状癌的关系  

Relationship between iodine nutritional status,urinary iodine concentration and papillary thyroid carcinoma

作　　者：樊玉霞[1] 燕豪 姜娜娜 刘征[1] 王晓明[1] 袁青领[1] 卢秀波[1] FAN Yuxia;YAN Hao;JIANG Nana;LIU Zheng;WANG Xiaoming;YUAN Qingling;LU Xiubo(Department of Thyroid Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院甲状腺外科,郑州450052

出　　处：《郑州大学学报（医学版）》2021年第2期153-156,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关计划项目(172102310078)。

摘　　要：目的:探讨碘营养状况和尿碘浓度与甲状腺乳头状癌(PTC)的关系。方法:收集2018年11月至2019年4月行手术治疗的500例PTC患者、100例结节性甲状腺肿患者的资料。生化法检测术前晨起空腹尿液中碘浓度。实时荧光定量PCR法检测病灶组织中BRAF基因V600E突变状态。结果:①PTC和结节性甲状腺肿患者尿碘浓度分别为(210.86±132.75)μg/L和(232.08±138.92)μg/L,碘不足/碘适宜/碘超适宜量/碘过量构成分别为93/198/111/98和15/32/31/22,两组尿碘浓度和碘营养状况差异均无统计学意义(P>0.05)。Logistic回归分析结果显示,校正年龄、性别因素后,尿碘浓度和碘营养状况与PTC的发生无明显关联(P>0.05)。②不同年龄、性别、肿瘤直径、淋巴结转移及BRAF基因V600E突变状态的PTC患者碘营养状况差异均无统计学意义(P>0.05)。Logistic回归分析结果显示,校正性别、年龄后,PTC患者碘营养状况和尿碘浓度与颈部淋巴结转移、瘤体直径、BRAF基因V600E突变均无明显关联(P>0.05)。结论:碘营养状况和尿碘浓度与PTC的发生发展无明显关联。Aim:To investigate the relationship between iodine nutritional status,urinary iodine concentration and papillary thyroid carcinoma(PTC).Methods:A total of 500 patients with PTC and 100 patients with nodular goiter from November 2018 to April 2019 were collected.The iodine concentration in fasting urine before operation was determinated by biochemical method.BRAF gene V600E mutation in lesion was detected by real-time fluorescence quantitative PCR.Results:The urinary iodine concentrations of patients with PTC or nodular goiter were(210.86±132.75)or(232.08±138.92)μg/L,respectively;the composition of iodine deficiency/iodine suitability/iodine supersuitability/iodine excess was 93/198/111/98 and 15/32/31/22,respectively;and there was no significant differences in urinary iodine concentration or iodine nutritional status between the two groups(P>0.05).Logistic regression analysis showed that there was no significant relation between iodine nutritional status or urinary iodine concentration and PTC occurrence adjusted with age and sex(P>0.05).There were no significant difference in iodine nutritional status among PTC patients with different age,gender,tumor diameter,lymph node metastasis or BRAF V600E mutation status(P>0.05).Logistic regression analysis showed that there was no significant relation between PTC patients′iodine nutritional status or urinary iodine concentration,and cervical lymph node metastasis,tumor diameter and BRAF V600E mutation adjusted with age and sex(P>0.05).Conclusion:There may be no significant relationship between iodine nutritional status or urinary iodine concentration and occurrence and development of PTC.

关 键 词：甲状腺乳头状癌 尿碘 碘营养状况 BRAF基因V600E 

分 类 号：R736.1[医药卫生—肿瘤]