阿戈美拉汀治疗抑郁症的临床研究  

Clinical research of Agomelatin in the treatment of depression

作　　者：杜莉辉 黄金荣 邹称林 徐晨雯 DU Li-hui;HUANG Jin-rong;ZOU Cheng-lin;XU Chen-wen(Department of Sleep Medicine,Ganzhou People′s Hospital,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市人民医院睡眠医学科,江西赣州341000

出　　处：《中国当代医药》2021年第10期106-108,116,共4页China Modern Medicine

基　　金：江西省赣州市指导性科技计划项目(GZ2017ZSF 163)。

摘　　要：目的探讨阿戈美拉汀治疗抑郁症的效果及安全性。方法选取2017年6月~2018年12月在赣州市人民医院就诊的197例抑郁症患者作为研究对象,按照双盲随机法分为观察组(101例,其中脱落3例,余98例)与对照组(96例,其中脱落2例,余94例)。对照组采用帕罗西汀治疗,观察组采用阿戈美拉汀治疗。比较两组的临床有效率、汉密尔顿抑郁量表(HAMD)评分、不良反应等。结果观察组的临床有效率为91.84%,与对照组的93.62%比较,差异无统计学意义(P>0.05);两组治疗第2、4周末的HAMD评分均低于治疗前,且观察组患者治疗第2、4周末的HAMD评分低于对照组,差异有统计学意义(P<0.05);两组患者的睡眠障碍、直立虚脱、身体疲倦、头痛、心悸、震颤、排尿困难、出汗、口干、便秘、嗜睡等不良反应发生率比较,差异无统计学意义(P>0.05)。观察组的性功能障碍发生率低于对照组,差异有统计学意义(P<0.05)。结论阿戈美拉汀与帕罗西汀均能安全有效地改善抑郁症患者的症状,临床疗效大致相当,但阿戈美拉汀对性功能影响较小。Objective To investigate the effect and safety of Agomelatine in the treatment of depression.Methods A total of 197 patients with depression in Ganzhou People′s Hospital from June 2017 to December 2018 were selected as the research objects,according to the double-blind random method,they were divided into the observation group(101 cases,3 cases of shedding and the rest 98 cases)and the control group(96 cases,2 cases of shedding and the rest 94 cases).The control group was treated with Paroxetine,and the observation group was treated with Agomelatine.The clinical effective rate,Hamilton depression scale(HAMD)score and adverse reactions were compared between the two groups.Results The clinical effective rate of the observation group was 91.84%,compared with 93.62%of the control group,the difference was not statistically significant(P>0.05).The HAMD scores of the two groups at the end of the 2nd and 4th weeks were lower than those before treatment,and the HAMD scores of the observation group at the end of the 2nd and 4th weeks were lower than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in the incidence of sleep disorders,upright collapse,physical fatigue,headache,palpitation,tremor,dysuria,sweating,dry mouth,constipation,sleepiness and other adverse reactions between the two groups(P>0.05).The incidence of sexual dysfunction in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Both Agomelatine and Paroxetine can safely and effectively improve the symptoms of patients with depression,and the clinical efficacy is roughly the same,but Agomelatine has little effect on sexual function.

关 键 词：抑郁症 性功能障碍 安全性 阿戈美拉汀 

分 类 号：R749.41[医药卫生—神经病学与精神病学]