基于国产与进口精确放疗设备在原发性肝癌与胰腺癌的临床剂量学评价研究  

Dosimetric Evaluation of Domestic and Imported Precision Radiotherapy Equipment in Primary Hepatocellular Carcinoma and Pancreatic Cancer

作　　者：丛小虎 宋伟男 解传滨[2] 戴相昆[2] 石楠 李学源 曲宝林[2] 徐寿平[2] CONG Xiaohu;SONG Weinan;XIE Chuanbin;DAI Xiangkun;SHI Nan;LI Xueyuan;QU Baolin;XU Shouping(Department of Radiation Physics,Qingdao Central Hospital,Qingdao Shandong 266042,China;Department of Radiotherapy,The First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Oncology Treatment Center,960 Hospital of PLA,Zibo Shandong 255300,China)

机构地区：[1]青岛市中心医院放射物理科,山东青岛266042 [2]解放军总医院第一医学中心放射治疗科,北京100853 [3]解放军第960医院肿瘤治疗中心,山东淄博255300

出　　处：《中国医疗设备》2021年第4期90-93,98,共5页China Medical Devices

基　　金：国家重点研发计划(2017YFC0112105)。

摘　　要：目的对比国产及进口精确放疗设备应用于原发性肝癌与胰腺癌放疗剂量学特点,评估国产精确放疗设备的临床应用情况。方法回顾性选取原发性肝癌(分为小肝癌和大肝癌)、胰腺癌患者各60例,对选取病例分别进行静态调强计划设计。采用加速器设备的不同将患者计划分为进口组和国产组。评估计划剂量学参数并实施剂量验证。结果所有计划靶区和危及器官受照剂量均能符合临床要求。原发性肝癌患者均匀指数国产组均值略优于进口组,差异具有统计学差异(P<0.05);所有病例适形指数比较均无统计学差异(P>0.05),计划国产组肝脏V_(10)、V_(30)与进口组相比较均无统计学差异(P>0.05),原发性肝癌计划进口组肝脏D_(mean)显著低于国产组计划(P<0.05),小肝癌计划国产组脊髓D_(max)显著低于进口组(P<0.05)。结论国产设备和进口设备相比较能够完成常规调强计划设计与执行,其计划质量与剂量验证结果均与进口设备保持了良好的一致性,国产放疗设备基本能够满足精确放疗的临床需求。Objective The application of domestic and imported precision radiotherapy equipment in primary hepatocellular carcinoma and pancreatic cancer was compared to evaluate the operation of domestic precision radiotherapy equipment.Methods A total of 60 patients with primary hepatocellular carcinoma(divided into small and large hepatocellular carcinoma),and pancreatic cancer were selected retrospectively.IMRT plans were designed for selected cases.All plans were divided into domestic and imported groups.The planed dosimetry parameters and dose verification results were evaluated.Results The targets and organ at risk(OAR)of all research plans could meet the limited requirements.The homogeneity index(HI)of patients with primary hepatocellular carcinoma the domestic group was better than the imported group(P<0.05).There was no statistically significant difference in conformal index(CI)between all the groups(P>0.05).There was no statistical difference between the V_(10) and V_(30) of liver in the domestic group compared with the imported group(P>0.05).For the primary hepatocellular carcinoma plans,imported group liver D_(mean) was significantly lower than the domestic group(P<0.05).The spinal cord D_(max) of small hepatocellular carcinoma in domestic group was significantly lower than that in imported group(P<0.05).All dose verification results could meet the clinical requirements.Conclusion Compared with the imported equipment,the domestic equipment can complete the design and implementation of the conventional IMRT plan.the plan quality and dose verification results are in good agreement with the imported equipment.Domestic radiotherapy equipment can basically meet the clinical needs.

关 键 词：精确放疗 国产设备 进口设备 剂量学 肝癌 胰腺癌 

分 类 号：R73[医药卫生—肿瘤]