TSGF、GGT联合、VEGF检测对原发性肝癌TACE疗效的预测价值  

Predictive value of TSGF and GGT combined with VEGF detection in the efficacy of transcatheter arterial chemoembolization in patients with primary hepatocellular carcinoma

作　　者：周永祥[1] 首峰[1] 张景俊[1] 叶世富[1] ZHOU Yongxiang;SHOU Feng;ZHANG Jingjun;YE Shifu(Department of Oncology,Jianyang People's Hospital,Jianyang,Sichuan,China,641400)

机构地区：[1]简阳市人民医院肿瘤科,四川简阳641400

出　　处：《分子诊断与治疗杂志》2021年第3期466-469,473,共5页Journal of Molecular Diagnostics and Therapy

基　　金：四川省医学科研青年创新课题(Q16015)。

摘　　要：目的研究肿瘤特异性生长因子(TSGF)、γ-谷氨酰转肽酶(GGT)联合血管内皮生长因子(VEGF)检测对原发性肝癌(PHC)患者经动脉灌注化疗栓塞治疗(TACE)疗效的预测价值。方法收集66例2016年5月至2018年5月于本院行TACE治疗的PHC患者的肿瘤组织,根据随访期间内复发情况分为未复发组(n=41)及复发组(n=25)。比较PHC患者行TACE治疗前及治疗1个月后TSGF、GGT、VEGF水平变化;记录所有PHC患者在随访时间内复发情况,采用多元Logistic回归分析影响PHC患者TACE治疗后复发的危险因素,采用ROC曲线分析TSGF、GGT、VEGF及三者联合检测对PHC患者TACE疗效的预测价值。结果治疗后TSGF、GGT、VEGF水平均低于治疗前,差异有统计学意义(P<0.05)。复发组肝功能ChildPugh分级B级、术前甲胎蛋白>20 ng/mL、肿瘤直径>3 cm、肿瘤位置第二肝门旁及多发性肿瘤者较未复发组多,复发组TSGF、GGT、VEGF水平较未复发组高,差异有统计学意义(P<0.05)。经Logistic回归分析发现:术前甲胎蛋白、TSGF、GGT、VEGF水平为影响PHC患者TACE治疗后复发的独立危险因素(P<0.05)。TSGF、GGT、VEGF及三者联合曲线下面积以三者联合最高。结论 TSGF、GGT及VEGF水平为影响PHC患者TACE治疗后复发的独立危险因素,联合三者检测可增加对PHC患者TACE治疗疗效的预测价值。Objective To study the predictive value of tumor specific growth factor(TSGF),γ-glutamyl transpeptidase(GGT)combined with vascular endothelial growth factor(VEGF)detection for the efficacy of transcatheter arterial chemoembolization(TACE)in patients with primary hepatocellular carcinoma(PHC). Methods The tumor tissues from 66 patients with PHC treated with TACE in our hospital from May2016 to May 2018 were collected. According to the recurrence during the follow-up period,they were divided into the non-recurrence group(n=41)and the recurrence group(n=25). The changes of TSGF,GGT,and VEGF levels before TACE treatment and 1 month after treatment in PHC patients were compared. The recurrence of all PHC patients was recorded during the follow-up period. The multivariate logistic regression analysis was used to analyze the risk factors of recurrence after TACE treatment in PHC patients. The ROC curve was used to analyze the predictive value of TSGF,GGT,VEGF and the combined detection of the three on the TACE efficacy in PHC patients. Results The levels of TSGF,GGT and VEGF after treatment were lower than those before treatment(P<0.05). There are more patients with liver function at Child-Pugh grade B,preoperative alpha-fetoprotein>20 ng/m L,tumor diameter>3 cm,tumor location next to the second hepatic portal and multiple tumors in the recurrence group than in the non-recurrence group. The levels of TSGF,GGT and VEGF in the recurrence group were higher than those in the non-recurrence group(P<0.05). Logistic regression analysis showed that the preoperative levels of alpha-fetoprotein,TSGF,GGT,and VEGF were independent risk factors that affect the recurrence of PHC patients after TACE treatment(P<0.05). The area under the combined curve was the highest. Conclusion The levels of TSGF,GGT and VEGF are independent risk factors that affect the recurrence of PHC patients after TACE treatment. The combined detection of the three can increase the predictive value of the efficacy of TACE treatment in PHC patients.

关 键 词：TSGF GGT VEGF 经动脉灌注化疗栓塞治疗 

分 类 号：R735.7[医药卫生—肿瘤]