隆突性皮肤纤维肉瘤的诊疗进展  

Research Progress in Diagnosis and Treatment of Dermatofibrosarcoma Protuberans

作　　者：刘珍如 周园 刘梦茜 王晓晴(综述) 王大光(审校)[1] LIU Zhen-ru;ZHOU Yuan;LIU Meng-xi;WANG Xiao-qing;WANG Da-guang(Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)

机构地区：[1]南京医科大学第一附属医院皮肤科,江苏南京210029

出　　处：《中国美容医学》2021年第3期171-174,共4页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金(编号:81000703、81472896);江苏省自然科学基金(编号:BK2009437);江苏省六大人才高峰资助项目(编号:2015-WSW-026)。

摘　　要：隆突性皮肤纤维肉瘤(Dermatofibrosarcoma protuberans,DFSP)是一种低度恶性肿瘤,早期DFSP临床症状不典型、特异性低,导致临床医师容易漏诊、误诊,此外,DFSP经手术治疗后仍有高复发率,部分病变更会出现纤维肉瘤化改变,增加其转移风险、并提示预后不佳。近年来,许多研究开始关注DFSP的诊断及治疗,透过皮肤镜、病理活检帮助医师早期诊断,提高疾病检出率,并通过手术、放疗及化疗等治疗,有效降低病变复发率、避免远处转移,本文就DFSP的最新治疗进展作一综述。Due to the atypical and low specificity clinical symptoms in early stage,Dermatofibrosarcoma protuberans(DFSP)is a low grade malignant tumor which might likely be misdiagnosis.In addition,even after surgical treatment DFSP still has a high recurrence rate.Lesions with fibrosarcomatous changes were associated with increased the risk of metastasis and poor prognosis.In recent years,many studies have begun to focus on the diagnosis and treatment of DFSP.Recent study showed with dermoscopy and pathological biopsy can help with early diagnosis and signicfanctly improve the detection rate.Also,with optimal treatment through surgery,radiotherapy and chemotherapy,recurrence and distant metastasis rate could be effectively reduced.This article reviews the recent progress of DFSP.

关 键 词：隆突性皮肤纤维肉瘤 纤维肉瘤样隆突性皮肤纤维肉瘤 莫氏手术 皮肤镜 伊马替尼 

分 类 号：R739.5[医药卫生—肿瘤]