重复经颅磁刺激联合度洛西汀治疗脑梗死后抑郁焦虑的临床效果及对日常生活能力的影响  

Effect of Low Frequency Repetitive Transcranial Magnetic Stimulation Combined with Duloxetine in the Treatment of Depression and Anxiety after Cerebral Infarction and Its Influence on Activity of Daily Living

作　　者：刘殿勋[1] 杜冬青[1] 孙凤春[2] LIU Dianxun;DU Dongqing;SUN Fengchun(Jining Mental Hospital,Jining 272051,China;不详)

机构地区：[1]山东省济宁市精神病防治院,山东济宁272051 [2]济宁医学院附属医院

出　　处：《中国医学创新》2021年第6期38-42,共5页Medical Innovation of China

摘　　要：目的:探讨重复经颅磁刺激联合度洛西汀治疗脑梗死后抑郁焦虑的临床效果及对日常生活能力的影响。方法:选取2018年6月-2020年3月本院收治的60例脑梗死后伴发抑郁焦虑的患者,按双盲抽签的方式将其分为对照组和观察组,各30例。对照组给予功能康复训练联合度洛西汀治疗。观察组在对照组的基础上给予低频重复经颅磁刺激。比较两组治疗前及治疗4、8周后两组汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、美国国立卫生院神经功能缺损程度(NIHSS)及改良Barthel指数(MBI)评分,比较两组不良反应发生情况及治疗效果。结果:治疗4、8周后,观察组HAMD、HAMA及NIHSS评分均低于对照组,且MBI评分高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。观察组治疗总有效率高于对照组(P<0.05)。结论:低频经颅磁刺激联合度洛西汀治疗脑梗死后抑郁焦虑可改善患者的抑郁焦虑症状,促进神经功能康复,提高患者日常生活活动能力,且相对安全。Objective:To investigate the clinical effect of low frequency repetitive transcranial magnetic stimulation combined with Duloxetine in the treatment of depression and anxiety after cerebral infarction and its effect on ability of daily living.Method:A total of 60 patients with depression and anxiety after cerebral infarction admitted to our hospital from June 2018 to March 2020 were selected.They were divided into control group and observation group by double-blind lottery,30 cases in each group.The control group was treated with functional rehabilitation training combined with Duloxetine,the observation group was treated with low frequency repetitive transcranial magnetic stimulation on the basis of the control group.Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),national institute of health stroke scale(NIHSS)and modified Barthel index(MBI)scores were compared between two groups before treatment,after 4 and 8 weeks of treatment.The incidence of adverse reaction and treatment effect were compared between the two groups.Result:After 4 and 8 weeks of treatment,the scores of HAMD,HAMA and NIHSS in the observation group were lower than those in the control group,and the MBI scores in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reaction between two groups(P>0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).Conclusion:Low frequency transcranial magnetic stimulation combined with Duloxetine in the treatment of depression and anxiety after cerebral infarction can improve the symptoms of depression and anxiety,promote neurological rehabilitation,and improve the ability of daily living activities of patients,and it is relatively safe.

关 键 词：低频重复经颅磁刺激 脑梗死 抑郁 焦虑 

分 类 号：R743.33[医药卫生—神经病学与精神病学]