血必净注射液辅助治疗慢性阻塞性肺疾病急性加重期临床效果及对细胞免疫功能的影响  

Clinical Effect of Xuebijing Injection in Adjuvant Therapy of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Its Effect on Cellular Immune Function

作　　者：张姗[1] 张玲慧[2] 张志军[2] 高继霞[2] 包宪霞[2] 孙洁 高晓粉 陈燕[2] ZHANG Shan;ZHANG Ling-hui;ZHANG Zhi-jun;GAO Ji-xia;BAO Xian-xia;SUN Jie;GAO Xiao-fen;CHEN Yan(Department of Respiratory Medicine,Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Cangzhou,Hebei 061000,China;Department of Internal Medicine,Shijiazhuang Medical College,Shijiazhuang 050071,China)

机构地区：[1]河北省沧州中西医结合医院呼吸内科,河北沧州061000 [2]石家庄医学高等专科学校内科教研室,石家庄050071

出　　处：《临床误诊误治》2021年第4期28-33,共6页Clinical Misdiagnosis & Mistherapy

基　　金：河北省科技厅研究课题计划(20160842);石家庄市科学技术研究与发展指导计划项目(161462763)。

摘　　要：目的评价血必净注射液辅助治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床效果、运动耐力及对血清炎性介质和细胞免疫功能的影响。方法选取2016年6月—2020年6月就诊的192例AECOPD,按治疗方法分为观察组和对照组,每组96例。对照组给予AECOPD常规治疗,观察组在对照组基础上联合血必净注射液治疗。观察比较2组临床疗效,治疗前后动脉血气分析指标、运动耐力、血清炎性介质水平及细胞免疫功能的变化,以及治疗期间不良反应的发生情况。结果治疗后,观察组总有效率为94.79%,对照组为79.17%,观察组明显高于对照组,差异有统计学意义(P<0.01)。治疗后,2组动脉血气分析指标、运动耐力、血清炎性介质水平及细胞免疫功能均较治疗前明显改善,且观察组明显优于对照组,差异具有统计学意义(P<0.05,P<0.01)。治疗过程中2组均无严重不良反应出现。结论临床应用血必净注射液辅助治疗AECOPD,不仅可提高临床疗效,还可改善患者运动耐力,降低血清炎性介质水平,以及改善细胞免疫功能,且安全性较好。Objective To evaluate the clinical efficacy and exercise endurance of Xuebijing injection in adjuvant therapy of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and its effect on serum inflammatory mediators and cellular immune function.Methods A total of 192 cases of AECOPD treated during June 2016 and June 2020 were divided into observation group and control group according to different treatment methods(n=96 in each group).The control group was given routine treatment with AECOPD,and the observation group was treated with Xuebijing injection on the basis of treatment for control group.The clinical efficacy,the changes of arterial blood gas level,exercise endurance,serum inflammatory mediators and cellular immune function before and after treatment,as well as incidence rate of adverse reactions during treatment were observed and compared in two groups.Results After treatment,the total effective rate of the observation group(94.79%)was significantly higher than 79.17%in control group(P<0.01).After treatment,the arterial blood gas level,activity endurance,serum inflammatory mediators and cellular immune function were significantly improved in both groups,and the indicators were significantly better in observation group than those in control group(P<0.05,P<0.01).No serious adverse reactions were found in both groups during the treatment.Conclusion Clinical application of Xuebijing injection in adjuvant therapy of AECOPD patients may not only improve the clinical efficacy,but also improve the patient's exercise endurance,reduce the level of serum inflammatory mediators,and improve the cellular immune function with better safety.

关 键 词：肺疾病 慢性阻塞性 血必净注射液 血气分析 身体耐力 T淋巴细胞亚群 

分 类 号：R563.9[医药卫生—呼吸系统]