药物联合血管内Wingspan支架手术治疗颅内动脉狭窄临床研究  

Clinical study on treatment of intracranial artery stenosis with drugs combined with endovascular Wingspan stent surgery

作　　者：王彦阔 焦淑洁[2] 孙丽萍 王志强 WANG Yankuo;JIAO Shujie;SUN Liping;WANG Zhiqiang(Pingdingshan Second People’s Hospital,Pingdingshan 467000,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]平顶山市第二人民医院,河南平顶山467000 [2]郑州大学第一附属医院,河南郑州450052

出　　处：《中国实用神经疾病杂志》2021年第3期241-246,共6页Chinese Journal of Practical Nervous Diseases

基　　金：2017年河南省医药卫生科技创新项目(编号:2017A0329)。

摘　　要：目的评价药物联合血管内Wingspan支架手术治疗颅内动脉狭窄的临床效果。方法颅内动脉狭窄患者168例,依据随机数字表法分成观察组和对照组,每组84例。对照组给予单纯药物治疗(如拜阿司匹林、波立维、立普妥),观察组在对照组基础上联合血管内Wingspan支架手术,比较2组患者随访中各时期卒中复发率、狭窄加重或复发情况。结果观察组随访中总卒中发生率、狭窄加重或复发概率均明显低于对照组,差异均有统计学意义(P<0.01);2组治疗后第1月神经功能改善情况比较差异无统计学意义(P>0.05);2组患者神经功能均于第4月后改善明显(P<0.01);观察组第4、7、10、13月神经功能改善情况明显优于对照组,差异有统计学意义(P<0.01)。结论药物联合血管内Wingspan支架手术能有效改善颅内动脉狭窄患者神经功能,防止卒中复发及狭窄加重或复发。Objective To discuss the clinical effect of drug combined endovascular Wingspan stent in the treatment of intracranial artery stenosis.Methods There were 168 cases of intracranial artery stenosis patients were diagnosed and treated in our hospital.According to random number table method,the patients were divided into observation group and control group,and 84 cases in each group.Giving the control of simple medication(Aspirin enteric-coated tablets,Plavix,Lipitor),the observation group in the control group on the basis of the combined use of intravascular Wingspan stents,compare two groups of patients with recurrence during follow-up period of each stroke,narrow to aggravate or recurrence probability index.Results The incidence of total stroke and the probability of aggravation of stenosis or recurrence in the observation group during follow-up were significantly lower than those in the control group,and the differences were statistically significant(P<0.01);there was no significant difference in the improvement of neurological function between the two groups in the first month after treatment(P>0.05);the nerve function of the patients in the two groups improved significantly in the fourth month(P<0.01);the improvement of the nerve function in the observation group was significantly better than that of the control group in the fourth,seventh,tenth,and thirteenth months,and the difference was statistically significant(P<0.01).Conclusion The clinic treatment of drug combined with endovascular Wingspan stent surgery can effectively improve neural function in patients with intracranial artery stenosis,prevention and treatment of recurrent stroke and narrow aggravating or recurrence,has high clinical value.

关 键 词：Wingspan支架手术 颅内动脉狭窄 拜阿司匹林 神经功能 波立维 

分 类 号：R743[医药卫生—神经病学与精神病学]