脑卒中干预途径:靶向NMDA受体  

Stroke intervention pathway:targeting NMDA receptor

作　　者：孙华利 毛森林[1] 王心悦[2] 王毅飞[1] 付锦[1] SUN Huali;MAO Senlin;WANG Xinyue;WANG Yifei;FU Jin(The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China;Harbin Medical Sciences University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150000 [2]哈尔滨医科大学,黑龙江哈尔滨150000

出　　处：《中国实用神经疾病杂志》2021年第3期265-270,共6页Chinese Journal of Practical Nervous Diseases

基　　金：黑龙江省省属高等学校基本科研业务费基础研究项目(编号:2019-KYYWF-0351);黑龙江省大学生创新创业训练计划项目(编号:S202010226032)。

摘　　要：NMDA(N-甲基-D-天冬氨酸)受体在缺血性脑卒中所致兴奋性神经元死亡中起重要作用,但NMDAR阻滞剂在临床上一直未能取得理想效果。相关研究已表明NMDAR的不同亚基及受体下游的许多特异性效应器对神经元的生存和死亡起重要作用。本文总结了这些领域的最新研究进展,并着重探讨NMDAR下游信号通路,以期为治疗脑卒中提供更有前景的治疗方法。NMDA(N-methyl-D-aspartate)receptor plays an important role in the death of excitatory neurons caused by ischemic stroke,but NMDA blockers have not achieved ideal results in clinical practice.Related studies have shown that different subunits of NMDAR,as well as many specific effectors downstream of the receptor,play an important role in the survival and death of neurons.In this review,we summarize the latest research progress in these fields,and focus on the downstream signal pathway of NMDAR,so as to provide a more promising treatment for stroke.

关 键 词：NMDA受体 脑卒中 兴奋性毒性 双重作用 下游信号通路 

分 类 号：R743.3[医药卫生—神经病学与精神病学]