重复经颅磁刺激联合传统康复治疗对孤独症儿童干预效果的Meta分析  

Repetitive transcranial magnetic stimulation treatment for autism spectrum disorders of Meta-analysis

作　　者：陆翠薇 李德阳 夏禧凤 吴玥琳 廖铭璐 胡思婷 张雪琴[1] LU Cuiwei;LI Deyang;XIA Xifeng;WU Yuelin;LIAO Minglu;HU Siting;ZHANG Xueqin(The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,Guangdong 511436,China)

机构地区：[1]广州医科大学广州医科大学附属脑科医院,广州511436

出　　处：《福建医药杂志》2021年第2期11-14,共4页Fujian Medical Journal

基　　金：2019年广东省本科高校教学质量与教学改革工程项目;2016年第三批广州市教育系统创新学术团队项目(1201610032)。

摘　　要：目的通过Meta分析系统评价重复经颅磁刺激(rTMS)联合传统康复治疗对孤独症儿童的干预效果。方法通过全面检索知网、维普、万方、中国生物医学文献数据库。纳入文献均为2016年后的随机对照试验,样本均为12岁以下儿童,并以儿童孤独症评定量表(CARS)评分作为检验效应指标。通过Review Manager 5.3对原始数据进行异质性检验,并采用固定效应模型进行分析,用漏斗图检验发表偏倚。结果初步检索得到266篇文献,按照标准经过筛选和排查后最终纳入Meta分析的研究共7篇,共490名儿童。用固定效应模型合并效应量后得到Z=12.64,漏斗图检验后提示不存在发表偏倚(P<0.001)。结论对于孤独症儿童,重复经磁颅刺激联合传统康复治疗干预要优于传统康复治疗的干预效果。Objective To compare and analyze the intervention effect of the combination of repetitive transcranial magnetic stimulation(rTMS)and traditional rehabilitation therapy with the traditional rehabilitation therapy on autistic children.Methods Comprehensive retrieval was carried out through the CNKI,VIP,Wanfang and China biology medicine disc databases.All the included articles were randomized controlled trials after 2016.The samples were children under 12 years old,and the effect was evaluated using CARS score.The test for heterogeneity and sensitivity analysis of the original data were performed using Review Manager 5.3.The results were analyzed with the fixed effect model,and publication bias was tested by the funnel plot.Results A total of 290 articles were retrieved preliminarily.Finally,seven articles involving 490 children were included in the Meta-analysis after screening according to the criteria.Fixed effect model combined with effect size obtained Z=12.64,P<0.001.The funnel plot suggested no publication bias.Conclusion For autistic children,rTMS combined with traditional rehabilitation therapy is superior to traditional rehabilitation therapy alone in intervention effect.

关 键 词：孤独症 重复经颅磁刺激 康复治疗 META分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]