Erbin在肺鳞状细胞癌组织中的表达及其与患者预后的关系  

Erbin expression in squamous cell carcinoma of the lung and its relationship with prognosis

作　　者：张丹 田姗 李翔 牟尚东 ZHANG Dan;TIAN Shan;LI Xiang;MOU Shangdong(Department of OncologyⅠ,3201 Hospital,Hanzhong,Shaanxi 723000,China)

机构地区：[1]三二〇一医院肿瘤内一科,陕西省汉中市723000

出　　处：《中南医学科学杂志》2021年第2期223-227,共5页Medical Science Journal of Central South China

摘　　要：目的探讨Erbin在肺鳞状细胞癌中的表达及其与患者预后的关系。方法对手术切除的80例肺鳞状细胞癌组织、80例癌旁正常肺组织的临床特征及生存资料进行回顾性分析。采用免疫组织化学法检测Erbin在肺鳞状细胞癌组织、癌旁正常肺组织中的表达情况,分析其与肺鳞状细胞癌的相关性,并采用Cox回归模型探讨影响患者预后的相关因素。结果肺鳞状细胞癌组织Erbin阳性率明显高于癌旁正常肺组织(P<0.05)。肺鳞状细胞癌组织Erbin的阳性表达与肿瘤分化类型、肿瘤浸润深度、临床TNM分期、淋巴结转移相关(P<0.05)。Erbin表达阴性患者术后1、3、5年生存率均明显高于Erbin表达阳性患者(P<0.001)。不同分化类型、临床肿瘤TNM分期、是否伴有淋巴结转移、肿瘤浸润深度、是否Erbin阳性表达的肺鳞状细胞癌患者生存率比较差异有显著性(P<0.05)。临床分期高(Ⅲ期)、伴有淋巴结转移、浸润深度>深层肌肉层、分化类型(高分化)、Erbin表达(阳性)等因素为肺鳞状细胞癌患者预后的独立危险因素(P<0.05)。结论Erbin阳性表达肺鳞状细胞癌恶性程度高、肿瘤浸润深、多为高分化类型,Erbin阳性表达肺鳞状细胞癌患者易发生淋巴结转移,临床分期高,生存率低,预后较差。Aim To investigate the relationship between the expression of Erbin and the prognosis of lung squamous cell carcinoma.Methods The clinical features and survival data of 80 cases of lung squamous cell carcinoma and 80 cases of normal lung tissue adjacent to carcinoma were analyzed retrospectively.Immunohistochemical method was used to detect the expression of Erbin in lung squamous cell carcinoma tissues and adjacent normal lung tissues,and the correlation between Erbin and lung squamous cell carcinoma was analyzed.Cox regression model was used to explore the related factors affecting the prognosis of patients.Results The positive rate of Erbin in lung squamous cell carcinoma was significantly higher than that in adjacent normal lung tissues(P<0.05).The positive expression of Erbin in lung squamous cell carcinoma was correlated with tumor differentiation type,tumor invasion depth,clinical TNM stage and lymph node metastasis(P<0.05).The 1,3,and 5-year survival rates of Erbin negative patients were significantly higher than those of Erbin positive patients(P<0.001).There were significant differences in survival rate among patients with different differentiation types,TNM stage,lymph node metastasis,depth of tumor invasion and Erbin positive expression(P<0.05).High clinical stage(stageⅢ),lymph node metastasis,depth of invasion>deep muscle layer,differentiation type(well differentiated),Erbin expression(positive)were independent risk factors for the prognosis of patients with lung squamous cell carcinoma(P<0.05).Conclusion Erbin positive squamous cell carcinoma of the lung is characterized by high malignancy,deep invasion,high differentiation,easy lymph node metastasis,late clinical stage,low survival rate and poor prognosis.

关 键 词：ERBIN 肺鳞状细胞癌 临床特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]