环状RNA在宫颈癌发生发展中作用的研究进展  

The research progress of circular RNAs in the development and progression of cervical cancer

作　　者：孙玮 李江 杨卓煜 郑亚迪 吴峥 温艳 杭栋 李霓 Sun Wei;Li Jiang;Yang Zhuoyu;Zheng Yadi;Wu Zheng;Wen Yan;Hang Dong;Li Ni(Department of Gynecology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Epidemiology,School of Public Health,Nanjing Medical University,Nanjing 211166,China;Office of Cancer Screening,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]南京医科大学第一附属医院江苏省人民医院妇科,南京210029 [2]南京医科大学公共卫生学院流行病学系,南京211166 [3]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院癌症早诊早治办公室,北京100021

出　　处：《中华预防医学杂志》2021年第3期409-412,共4页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81673265)。

摘　　要：宫颈癌是最常见的妇科恶性肿瘤之一,发病率和死亡率位居前列。高危型人乳头状瘤病毒(human papilloma virus,HPV)持续感染是其发病的主要原因,以16、18型最为典型。环状RNA(circular RNA,circRNA)是RNA前体通过首尾共价相连,形成的单链环状非编码RNA,具有miRNA海绵、结合RNA结合蛋白(RBP)以及翻译蛋白质等功能,在多种疾病的进展中发挥重要作用。目前,circRNA在宫颈癌中的研究尚处于早期阶段,现就环状RNA在高危HPV感染、宫颈癌发生发展和放化疗敏感性方面的新进展进行阐述。Cervical cancer is one of the most common gynecological malignancies,and its morbidity and mortality are among the highest.Persistent infection of high-risk types of HPV is the main reason for its onset,with types 16 and 18 being the most prevalent.Circular RNA(circRNA)is a single-stranded circular non-coding RNA formed by covalent end to end bonding of RNA precursors.It has functions such as miRNA sponge,binding RNA binding protein(RBP),and protein translation,and plays an important role in the occurrence and development of various diseases.At present,the research on circRNA in cervical cancer is still at an early stage.The latest progress of circRNA in high-risk HPV infection,occurrence and development of cervical cancer,and sensitivity to chemoradiotherapy is briefly reviewed.

关 键 词：宫颈癌 人乳头状瘤病毒 环状RNA miRNA海绵 

分 类 号：R737.33[医药卫生—肿瘤]